Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
Products
Antibodies
ELISA and Assay Kits
Research Areas
Infectious Disease
Resources
Purchasing
Reference Material
Contact Us
Locations
Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Telephone Numbers
Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
Contact Us
Additional Contact Details
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
ALK2 / ACVR1
activin A receptor, type I
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
| Gene Name: | activin A receptor, type I |
| Family/Subfamily: | Protein Kinase , Activin/TGFb |
| Synonyms: | ACVR1, Activin A receptor type I, Activin A receptor, type I, ACTR-I, ActRIA, ACVR1A, ALK2, Activin receptor-like kinase 2, Activin receptor type-1, ACTRI, ACVRLK2, ALK-2, Activin receptor type I, Actr1, FOP, Hydroxyalkyl-protein kinase, SKR1, TSRI, TSR-I, Tsk7L |
| Target Sequences: | NM_001105 NP_001096.1 Q04771 |
Publications (3)
1
Coco is a dual activity modulator of TGFß signaling. Deglincerti A, Haremaki T, Warmflash A, Sorre B, Brivanlou AH. Development (Cambridge, England). 2015 142:2678-85. (IP; Xenopus laevis)
[Full Text Article]
[PubMed:26116664]
[PMC:PMC4529031]
Related Antibodies: LS-B2010.
2
OKlahoma Nitrone-007: novel treatment for diffuse intrinsic pontine glioma. Lincy Thomas, Nataliya Smith, Debra Saunders, Michelle Zalles, Rafal Gulej, Megan Lerner, Kar-Ming Fung, Angel M Carcaboso, Rheal A Towner. Journal of translational medicine. 2020 November;18:424. [Full Text Article]
[PubMed:33168005]
[PMC:PMC7654606]
Related Antibodies: LS-B11761.
3
Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans. Clementi C, Tripurani SK, Large MJ, Edson MA, Creighton CJ, Hawkins SM, Kovanci E, Kaartinen V, Lydon JP, Pangas SA, DeMayo FJ, Matzuk MM. PLoS genetics. 2013 Nov;9:e1003863. [Full Text Article]
[PubMed:24244176]
[PMC:PMC3828128]
Related Antibodies: LS-B6835.
☰ Filters
Products
Antibodies
(76)
Proteins
(18)
ELISA Kits
(2)
Type
Custom
(1)
Over-Expression Lysate
(4)
Primary
(76)
Recombinant
(14)
Sandwich
(1)
Target
ALK2 / ACVR1
(96)
Reactivity
Human
(65)
Mouse
(40)
Rat
(9)
Bat
(5)
Bovine
(8)
Chicken
(1)
Chimpanzee
(6)
Dog
(6)
Gibbon
(6)
Goat
(3)
Guinea pig
(3)
Hamster
(1)
Horse
(8)
Monkey
(8)
Pig
(8)
Rabbit
(5)
Xenopus
(1)
Application
IHC
(28)
IHC-P
(15)
WB
(70)
Flo
(3)
ELISA
(28)
ICC
(1)
IF
(1)
Peptide-ELISA
(3)
Host
rabbit
(68)
mouse
(3)
goat
(4)
sheep
(1)
Product Group
IHCPlus
(6)
PathPlus Neuro
(2)
Isotype
IgG
(33)
IgG1
(2)
IgG1,k
(1)
Clonality
monoclonal mc
(3)
polyclonal pc
(73)
Clone
2C1E8
(1)
2D5
(1)
2E2C11
(1)
Format
96-Well Microplate
(1)
96-Well Strip Plate
(1)
APC
(3)
APC Conjugated
(6)
Azide-free
(3)
Biotin Conjugated
(10)
Cy3 Conjugated
(3)
Cy7 Conjugated
(3)
FITC Conjugated
(8)
HRP Conjugated
(8)
PE Conjugated
(6)
Unconjugated
(32)
Epitope
aa208-340
(24)
aa132-161
(7)
aa132-162
(7)
aa137-166
(7)
aa38-87
(4)
aa80-129
(4)
Extracellular Domain
(2)
Internal Region
(1)
aa138-170
(1)
aa147-161
(1)
aa20-125
(1)
aa496-509
(1)
aa6-34
(1)
aa85-123
(1)
Publications
No
(93)
Yes
(3)
Sample Type
Tissue Homogenates
(1)
Tag
6His, C-terminus
(2)
Fc, C-terminus
(1)
GST
(1)
GST, N-terminus
(1)
His
(3)
His-GST
(1)
His-Human IgG1 Fc
(1)
Human IgG1 Fc, C-terminus
(2)
Myc-DDK (Flag)
(6)
Species
Human
(13)
Mouse
(2)
Rat
(1)
Source
293T Cells
(2)
Baculovirus
(1)
E. coli
(3)
HEK 293 Cells
(4)
Human
(1)
Human Cells
(4)
Mammalian Cells
(1)
Wheat Germ Extract
(2)
Purification
Purified
(4)
Low Endotoxin Level
Low endotoxin level
(7)
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa496-509) Antibody
Xenopus, Bat, Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µg/$440
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa80-129) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa80-129) (HRP) Antibody
Mouse, Goat, Guinea pig, Bovine, Pig, Horse, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
Neuroscience
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa138-170) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$440
Neuroscience
ALK2 / ACVR1 Goat anti-Human Polyclonal (aa147-161) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
ALK2 / ACVR1 Mouse anti-Human Monoclonal (2E2C11) Antibody
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
100 µl/$459
ALK2 / ACVR1 Goat anti-Human Polyclonal (Extracellular Domain) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$951
ALK2 / ACVR1 Mouse anti-Human Monoclonal (2D5) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa38-87) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
ALK2 / ACVR1 Rabbit anti-Mouse Polyclonal (aa137-166) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa6-34) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa20-125) Antibody
Mouse, Human
ELISA, IF, IHC-P, WB
Unconjugated
50 µl/$460
ALK2 / ACVR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
0.1 mg/$460
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa132-162) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
ALK2 / ACVR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa85-123) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
HEK 293 Cells
Myc-DDK (Flag)
55 kDa
20 µg/$1,107
Human Cells
His-Human IgG1 Fc
Less than 1.0 EU/µg protein (determined by LAL method).
39.6 kDa
200 µg/$1,148
Human Cells
Human IgG1 Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
38.5 kDa
200 µg/$1,148
Human Cells
Human IgG1 Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
40 kDa
200 µg/$1,148
Fast Shipping
ALK2 / ACVR1 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
Fast Shipping
ALK2 / ACVR1 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
Fast Shipping
ALK2 / ACVR1 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
ALK2 / ACVR1 Rabbit anti-Mouse Polyclonal (aa137-166) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa132-162) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
Viewing 1-25
of 96
product results
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
