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ALCAM / CD166

activated leukocyte cell adhesion molecule

Activated leukocyte cell adhesion molecule (ALCAM)/cluster of differentiation (CD166) is a type I transmembrane cell adhesion molecule belonging to the Ig superfamily and a ligand for CD6 that is expressed on T lymphocytes. Homophilic (ALCAM-ALCAM) adhesion was shown to play important roles in tight cell-to-cell interaction and regulation of stem cell differentiation. While expressed in a wide variety of tissues, ALCAM is usually restricted to subsets of cells involved in dynamic growth and/or migration, including neural development, branching organ development, hematopoiesis, immune response and tumor progression.

Gene Name:	activated leukocyte cell adhesion molecule
Synonyms:	ALCAM, CD166 antigen, MEMD, CD166
Target Sequences:	NM_001627 NP_001618.2 Q13740

Publications (4)

GMP-compliant isolation and large-scale expansion of bone marrow-derived MSC. Fekete N, Rojewski MT, Fürst D, Kreja L, Ignatius A, Dausend J, Schrezenmeier H. PloS one. 2012 7:e43255. (Flo; Human) [Full Text Article] [PubMed:22905242] Related Antibodies: LS-C84947.

A novel molecular magnetic resonance imaging agent targeting activated leukocyte cell adhesion molecule as demonstrated in mouse brain metastasis models. Niloufar Zarghami, Manuel Sarmiento Soto, Francisco Perez-Balderas, Alexandre A Khrapitchev, Christina Simoglou Karali, Vanessa A Johanssen, Olaf Ansorge, James R Larkin, Nicola R Sibson. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2020 November;271678X20968943. [Full Text Article] [PubMed:33153376] [PMC:PMC8217895] Related Antibodies: LS-C292613.

Amniotic stromal stem cell-loaded hydrogel repairs cardiac tissue in infarcted rat hearts via paracrine mediators. Kashif Khan, Georges Makhoul, Bin Yu, Ghulam Jalani, Ida Derish, Alissa K Rutman, Marta Cerruti, Adel Schwertani, Renzo Cecere. Journal of tissue engineering and regenerative medicine. 2022 Feburary;16:110-127. [Full Text Article] [PubMed:34726328] Related Antibodies: LS-C35861.

GMP-compliant isolation and expansion of bone marrow-derived MSCs in the closed, automated device quantum cell expansion system. Rojewski MT, Fekete N, Baila S, Nguyen K, F[Character fc]rst D, Antwiler D, Dausend J, Kreja L, Ignatius A, Senseb[Character e9] L, Schrezenmeier H. Cell transplantation. 2013 22:1981-2000. [Full Text Article] [PubMed:23107560] Related Antibodies: LS-C86784.

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