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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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AKR1C4 / Chlordecone Reductase
aldo-keto reductase family 1, member C4
Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
| Gene Name: | aldo-keto reductase family 1, member C4 |
| Synonyms: | AKR1C4, 3-alpha-HSD, 3-alpha-HSD1, Chlordecone reductase, CDR, CHDR, DD-4, Dihydrodiol dehydrogenase 4, C11, DD4, HAKRA |
| Target Sequences: | NM_001818 NP_001809.3 P17516 |
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