AIM2

absent in melanoma 2

Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.

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Proteins (3)

Type

Recombinant (3)

Target

AIM2 (3)

Publications

No (3)

Tag

GST (2)

His, N-Terminal (1)

Species

Human (3)

Source

Baculovirus (1)

E. coli (1)

Wheat Germ Extract (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

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Human AIM2 Protein (Recombinant His, N-Terminal) (aa1-343) - LS-G25710

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

43.7 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human AIM2 Protein (Recombinant GST) (Full Length) - LS-G31636

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

64.9 kDa

Price:

2 µg/$439

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Human AIM2 Protein (Recombinant GST) (Met1-Thr343) - LS-G97139

Source:

Baculovirus

Tag:

GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

65.2 kDa

Price:

50 µg/$721

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