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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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AIM2

absent in melanoma 2

Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.

Gene Name: absent in melanoma 2
Synonyms: AIM2, Absent in melanoma 2, PYHIN4
Target Sequences: NM_004833 NP_004824.1 O14862

Filtered by: None
Target
AIM2 (56)
Reactivity
Human (56)
Mouse (7)
Rat (2)
Gibbon (3)
Horse (4)
Monkey (4)
Pig (8)
Rabbit (6)
Zebrafish (4)
Application
IHC (11)
IHC-P (3)
WB (48)
Flo (9)
ELISA (21)
ICC (7)
IF (14)
IP (1)
Peptide-ELISA (5)
Host
rabbit (47)
mouse (6)
goat (3)
Isotype
IgG (33)
IgG1 (2)
IgG2a,k (2)
IgM (1)
Clonality
monoclonal mc (5)
polyclonal pc (51)
Clone
3C4G11 (1)
7G12D1 (1)
812CT9.2.2.1 (1)
IMG10M2B3 (1)
IMG10M5G5 (1)
Format
AP Conjugated (2)
APC (1)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (5)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (3)
Unconjugated (31)
Epitope
aa1-343 (8)
aa4-32 (8)
N-Terminus (4)
Internal (2)
30-110 aa, Internal (1)
Ala78 (1)
aa14-215 (1)
aa15-27 (1)
aa29-78 (1)
aa321-335 (1)
aa51-100 (1)
aa89-103 (1)
aa93-342 (1)
Publications
No (56)
Showing 1-25 of 56 results

IHC-plus™ AIM2 Antibody (aa321-335) LS-B5945
Goat Polyclonal to Human AIM2
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-AIM2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Antibody staining of IFNbeta-treated WI-38 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

AIM2 Antibody (Internal) LS-C354127
Rabbit Polyclonal to Human AIM2
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $245.00
Immunohistochemical analysis of AIM2 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of AIM2 staining in Jurkat cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

AIM2 Antibody (aa4-32) LS-C156196
Rabbit Polyclonal to Human AIM2
Human
Flo, IF, WB
Unconjugated
400µl  $325.00
Confocal immunofluorescence of AIM2 Antibody with MCF-7 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).
Western blot of AIM2 Antibody in MCF-7, HL-60, K562, HeLa cell line lysates (35 ug/lane). AIM2 (arrow) was detected using the purified antibody.

AIM2 Antibody (N-Terminus) LS-C81558
Rabbit Polyclonal (IgG) to Human AIM2
Zebrafish, Horse, Mouse, Human, Monkey
WB
Unconjugated
100µl 0.5mg/ml  $365.00
Fetal lung lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

AIM2 Antibody (aa14-215) LS-C407895
Rabbit Polyclonal to Human AIM2
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100µg  $355.00
AIM2 antibody IHC-paraffin. IHC(P): Mouse Kidney Tissue.
AIM2 antibody IHC-paraffin. IHC(P): Rat Intestine Tissue.

AIM2 Antibody LS-C137251
Rabbit Polyclonal (IgG) to Human AIM2
Human
IHC, WB
Unconjugated
100µl  $275.00
Immunohistochemistry Image
Western blot Image

AIM2 Antibody (aa4-32) LS-C319389
Rabbit Polyclonal (IgG) to Human AIM2
Human
ELISA, Flo, IF, WB
Unconjugated
200µl  $590.00

AIM2 Antibody (aa4-32, Biotin) LS-C251075
Rabbit Polyclonal (IgG) to Human AIM2
Human
ELISA, Flo, ICC, IF, WB
Biotin Conjugated
200µl  $740.00

AIM2 Antibody (aa4-32, FITC) LS-C251076
Rabbit Polyclonal (IgG) to Human AIM2
Human
ELISA, Flo, ICC, IF, WB
FITC Conjugated
200µl  $740.00

AIM2 Antibody (aa4-32, APC) LS-C251074
Rabbit Polyclonal (IgG) to Human AIM2
Human
ELISA, Flo, ICC, IF, WB
APC Conjugated
200µl 0.35mg/ml  $740.00

AIM2 Antibody (aa4-32, AP) LS-C251072
Rabbit Polyclonal (IgG) to Human AIM2
Human
ELISA, Flo, ICC, IF, WB
AP Conjugated
200µl  $740.00

AIM2 Antibody (aa4-32, Azide-free, HRP) LS-C251077
Rabbit Polyclonal (IgG) to Human AIM2
Human
ELISA, Flo, ICC, IF, WB
HRP Conjugated, Azide-free
200µl  $740.00

AIM2 Antibody (aa4-32, PE) LS-C251078
Rabbit Polyclonal (IgG) to Human AIM2
Human
ELISA, Flo, ICC, IF, WB
PE Conjugated
200µl  $740.00

AIM2 Antibody (aa93-342) LS-C178548
Rabbit Polyclonal to Human AIM2
Human
ELISA, IHC, WB
Unconjugated
100µg  $275.00
Immunohistochemistry Image

AIM2 Antibody LS-C498354
Rabbit Polyclonal (IgG) to Human AIM2
Human
ELISA, IF, IHC, WB
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human testis tissue using AIM2 Antibody at dilution of 1:100
Immunofluorescent analysis of A549 cells using AIM2 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

AIM2 Antibody (30-110 aa, Internal) LS-C381956
Rabbit Polyclonal (IgG) to Human AIM2
Human
ELISA, IF, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of AIM2 antibody
Western blot of AIM2 antibody

AIM2 Antibody LS-C804624
Rabbit Polyclonal (IgG) to Human AIM2
Mouse, Human
ELISA, IF, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunofluorescence Image
Western blot Image

AIM2 Antibody (clone 7G12D1) LS-C669398
Mouse Monoclonal [clone 7G12D1] (IgG1) to Human AIM2
Human
ELISA, IF, WB
Unconjugated
0.1mg  $365.00

AIM2 Antibody LS-C659200
Rabbit Polyclonal (IgG) to Human AIM2
Human
ELISA, IHC, WB
Unconjugated
100µg  $405.00

AIM2 Antibody (Internal) LS-C137125
Rabbit Polyclonal (IgG) to Human AIM2
Human
ELISA, IHC, WB
Unconjugated
100µl  $275.00
Western blot Image

AIM2 Antibody (clone 3C4G11) LS-C669272
Mouse Monoclonal [clone 3C4G11] (IgG1) to Human AIM2
Human
ELISA, Flo
Unconjugated
0.1mg  $365.00

AIM2 Antibody (Ala78) LS-C192022
Rabbit Polyclonal to Human AIM2
Human
IHC, WB
Unconjugated
100µl  $345.00

AIM2 Antibody LS-C401421
Rabbit Polyclonal (IgG) to Human AIM2
Human
ELISA, IHC
Unconjugated
20µl 0.9mg/ml  $205.00; 60µl 0.9mg/ml  $235.00; 120µl 0.9mg/ml  $295.00; 200µl 0.9mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human lung cancer using AIM2 Polyclonal Antibody at dilution of 1:60.
Immunohistochemistry of paraffin-embedded Human lung cancer using AIM2 Polyclonal Antibody at dilution of 1:60.

AIM2 Antibody LS-C306161
Mouse Polyclonal (IgG) to Human AIM2
Human
IF, WB
Unconjugated
50µg  $560.00

AIM2 Antibody LS-C309372
Rabbit Polyclonal (IgG) to Human AIM2
Human
IP, WB
Unconjugated
100µl  $605.00
Showing 1-25 of 56 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).