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AGTR2 / AT2 Receptor

angiotensin II receptor, type 2

Type 2 Angiotensin Receptor (AT2) has been suggested to affect development, cell differentiation, apoptosis, and regeneration in various tissues. AT2 receptor has been shown to exert counteracting effects on cellular growth and differentiation, vascular tone, and the release of arginine vasopressin (AVP). In each condition, the AT2 receptor appears to down-modulate actions mediated by the AT1 receptor, resulting in decreased cellular proliferation, decreased levels of serum AVP levels, or decreased vasoconstrictor responses. Binding of angiotensin II to the AT2 receptor inhibits guanylate cyclase. Recently, AT2 receptor has been suggested to affect brain development and cognitive function (Vervoort et al. 2002).

Gene Name: angiotensin II receptor, type 2
Family/Subfamily: GPCR , Angiotensin
Synonyms: AGTR2, Angiotensin ii receptor type 2, Angiotensin II type-2 receptor, AT2 receptor, AT2, At2r, MRX88, Angiotensin ii at2, Angiotensin receptor 2, Type-2 angiotensin II receptor, ATGR2
Target Sequences: NM_000686 NP_000677.2 P50052

Publications (2)

1
A Novel Swine Model of Spontaneous Hypertension With Sympathetic Hyperactivity Responds Well to Renal Denervation. Li D, Wang Q, Zhang Y, Li D, Yang D, Wei S, Su L, Ye T, Zheng X, Peng K, Zhang L, Zhang Y, Yang Y, Ma S. American journal of hypertension. 2016 29:63-72. (WB; Human) [Full Text Article] [PubMed:25958303] Related Antibodies: LS-C135684.
2
Commercially available angiotensin II At2 receptor antibodies are nonspecific. Hafko R, Villapol S, Nostramo R, Symes A, Sabban EL, Inagami T, Saavedra JM. PloS one. 8:e69234. [Full Text Article] [PubMed:23840911] [PMC:PMC3698141] Related Antibodies: LS-C11856.

☰ Filters
Products
Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
AGTR2 / AT2 Receptor (6)
No (6)
6His-SUMO, N-terminus (1)
GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (2)
Human (3)
Rat (2)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Yeast (1)
Purified (2)
AGTR2 / AT2 Receptor Protein
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E. coli
GST, N-terminus
32.3 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
AGTR2 / AT2 Receptor Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
1 mg/$1,486; 100 µg/$451; 20 µg/$339
AGTR2 / AT2 Receptor Protein
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Yeast
His
6.9 kD
1 mg/$1,683; 100 µg/$499; 20 µg/$364
AGTR2 / AT2 Receptor Protein - 12.5% SDS-PAGE of human AGTR2 stained with Coomassie Blue
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Wheat Germ Extract
GST
67.6 kDa
2 µg/$439
AGTR2 / AT2 Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
41 kDa
20 µg/$150
AGTR2 / AT2 Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
41 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).