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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
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AGT / Angiotensinogen
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.Angiotensin-3: stimulates aldosterone release.Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
Gene Name:
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Reduced expression of angiotensin II and angiotensin receptor type 1 and type 2 in resistance arteries from nasal lesions in granulomatosis with polyangiitis (Wegener's granulomatosis). Dimitrijevic I, Rissler P, Luts L, Edvinsson L. Scandinavian journal of rheumatology. 2011 40:448-52. (ICC, IHC; Human)
[PubMed:21936613]
2
Partial restoration of cardio-vascular defects in a rescued severe model of spinal muscular atrophy. Shababi M, Habibi J, Ma L, Glascock JJ, Sowers JR, Lorson CL. Journal of molecular and cellular cardiology. 2012 52:1074-82. (WB; Mouse)
[PubMed:22285962]
[PMC:PMC3327806]
3
Improved Assay for Quantifying a Redox Form of Angiotensinogen as a Biomarker for Pre-Eclampsia: A Case-Control Study. Rahgozar S, Amirian T, Qi M, Shahshahan Z, Entezar-E-Ghaem M, Ghasemi Tehrani H, Miroliaei M, Krilis SA, Giannakopoulos B. PloS one. 2015 10:e0135905. (WB; Human)[Full Text Article]
[PubMed:26312482]
[PMC:PMC4552422]
Related Antibodies: LS-C80597.
4
Angiotensinogen and HLA class II predict bevacizumab response in recurrent glioblastoma patients. Urup T, Michaelsen SR, Olsen LR, Toft A, Christensen IJ, Grunnet K, Winther O, Broholm H, Kosteljanetz M, Issazadeh-Navikas S, Poulsen HS, Lassen U. Molecular oncology. 2016 October;10:1160-8. (Human)[Full Text Article]
[PubMed:27262894]
[PMC:PMC5423207]
Related Antibodies: LS-B6575.
5
Exploration of cardiometabolic and developmental significance of angiotensinogen expression by cells expressing the leptin receptor or agouti-related peptide. Sarah A Sapouckey, Lisa L Morselli, Guorui Deng, Chetan N Patil, Kirthikaa Balapattabi, Vanessa Oliveira, Kristin E Claflin, Javier Gomez, Nicole A Pearson, Matthew J Potthoff, Katherine N Gibson-Corley, Curt D Sigmund, Justin L Grobe. American journal of physiology. Regulatory, integrative and comparative physiology. 2020 May;318:R855-R869. [Full Text Article]
[PubMed:32186897]
[PMC:PMC7272763]
6
Persistent Renin-Angiotensin System Sensitization Months After Body Weight Recovery From Severe Food Restriction in Female Fischer Rats. Aline M A de Souza, Hong Ji, Xie Wu, Kathryn Sandberg, Crystal A West. Journal of the American Heart Association. 2020 July;9:e017246. [Full Text Article]
[PubMed:32674648]
[PMC:PMC7660733]
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PLEASE NOTE
For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).