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AGT / Angiotensinogen

angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.Angiotensin-3: stimulates aldosterone release.Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

Gene Name: angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: AGT, ANHU, Angiotensinogen, Pre-angiotensinogen, SERPINA8, Serpin A8
Target Sequences: NM_000029 NP_000020.1 P01019

Publications (6)

1
Reduced expression of angiotensin II and angiotensin receptor type 1 and type 2 in resistance arteries from nasal lesions in granulomatosis with polyangiitis (Wegener's granulomatosis). Dimitrijevic I, Rissler P, Luts L, Edvinsson L. Scandinavian journal of rheumatology. 2011 40:448-52. (ICC, IHC; Human) [PubMed:21936613]
2
Partial restoration of cardio-vascular defects in a rescued severe model of spinal muscular atrophy. Shababi M, Habibi J, Ma L, Glascock JJ, Sowers JR, Lorson CL. Journal of molecular and cellular cardiology. 2012 52:1074-82. (WB; Mouse) [PubMed:22285962] [PMC:PMC3327806]
3
Improved Assay for Quantifying a Redox Form of Angiotensinogen as a Biomarker for Pre-Eclampsia: A Case-Control Study. Rahgozar S, Amirian T, Qi M, Shahshahan Z, Entezar-E-Ghaem M, Ghasemi Tehrani H, Miroliaei M, Krilis SA, Giannakopoulos B. PloS one. 2015 10:e0135905. (WB; Human) [Full Text Article] [PubMed:26312482] [PMC:PMC4552422] Related Antibodies: LS-C80597.
4
Angiotensinogen and HLA class II predict bevacizumab response in recurrent glioblastoma patients. Urup T, Michaelsen SR, Olsen LR, Toft A, Christensen IJ, Grunnet K, Winther O, Broholm H, Kosteljanetz M, Issazadeh-Navikas S, Poulsen HS, Lassen U. Molecular oncology. 2016 October;10:1160-8. (Human) [Full Text Article] [PubMed:27262894] [PMC:PMC5423207] Related Antibodies: LS-B6575.
5
Exploration of cardiometabolic and developmental significance of angiotensinogen expression by cells expressing the leptin receptor or agouti-related peptide. Sarah A Sapouckey, Lisa L Morselli, Guorui Deng, Chetan N Patil, Kirthikaa Balapattabi, Vanessa Oliveira, Kristin E Claflin, Javier Gomez, Nicole A Pearson, Matthew J Potthoff, Katherine N Gibson-Corley, Curt D Sigmund, Justin L Grobe. American journal of physiology. Regulatory, integrative and comparative physiology. 2020 May;318:R855-R869. [Full Text Article] [PubMed:32186897] [PMC:PMC7272763]
6
Persistent Renin-Angiotensin System Sensitization Months After Body Weight Recovery From Severe Food Restriction in Female Fischer Rats. Aline M A de Souza, Hong Ji, Xie Wu, Kathryn Sandberg, Crystal A West. Journal of the American Heart Association. 2020 July;9:e017246. [Full Text Article] [PubMed:32674648] [PMC:PMC7660733]
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AGT / Angiotensinogen (34)
Human (10)
Mouse (8)
Rat (8)
Chicken (2)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
Sheep (1)
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12 x 8-Well Microstrips (3)
96-Well Microplate (5)
96-Well Strip Plate (23)
Antibody Pair and Standard (2)
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Yes (2)
Cell Culture Supernatants (4)
Cell Lysates (2)
EDTA Plasma (1)
Plasma (25)
Serum (26)
Tissue Homogenates (9)
Urine (2)
AGT / Angiotensinogen ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.63 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
AGT / Angiotensinogen ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$863
AGT / Angiotensinogen ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$818
AGT / Angiotensinogen ELISA Kit
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Sandwich
96-Well Strip Plate
Human
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates, Urine
1 Plate/$764
AGT / Angiotensinogen ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$782
AGT / Angiotensinogen ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
AGT / Angiotensinogen ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
250 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
AGT / Angiotensinogen ELISA Kit
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Sandwich
96-Well Microplate
Rat
62.5 - 4000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
AGT / Angiotensinogen ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
125 - 8000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
AGT / Angiotensinogen ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Rat
7.813 - 500 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
AGT / Angiotensinogen ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
AGT / Angiotensinogen ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Mouse
0.055 - 40 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$990
AGT / Angiotensinogen ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
AGT / Angiotensinogen ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Human
6.24 - 400 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates, Urine
500 Wells/$1,182; 1000 Wells/$1,747
AGT / Angiotensinogen ELISA Kit
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Sandwich
96-Well Microplate
Human
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
AGT / Angiotensinogen ELISA Kit
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Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$929
AGT / Angiotensinogen ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
AGT / Angiotensinogen ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
AGT / Angiotensinogen ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
AGT / Angiotensinogen ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
0.313 - 20 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
AGT / Angiotensinogen ELISA Kit
Select
Competitive EIA
96-Well Microplate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
AGT / Angiotensinogen ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
125 - 8000 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
AGT / Angiotensinogen ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
62.5 - 4000 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
AGT / Angiotensinogen ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
AGT / Angiotensinogen ELISA Kit
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Sandwich
96-Well Strip Plate
Sheep
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$760
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).