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AGT / Angiotensinogen

angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.Angiotensin-3: stimulates aldosterone release.Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

Gene Name: angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: AGT, ANHU, Angiotensinogen, Pre-angiotensinogen, SERPINA8, Serpin A8
Target Sequences: NM_000029 NP_000020.1 P01019

Publications (6)

1
Reduced expression of angiotensin II and angiotensin receptor type 1 and type 2 in resistance arteries from nasal lesions in granulomatosis with polyangiitis (Wegener's granulomatosis). Dimitrijevic I, Rissler P, Luts L, Edvinsson L. Scandinavian journal of rheumatology. 2011 40:448-52. (ICC, IHC; Human) [PubMed:21936613]
2
Partial restoration of cardio-vascular defects in a rescued severe model of spinal muscular atrophy. Shababi M, Habibi J, Ma L, Glascock JJ, Sowers JR, Lorson CL. Journal of molecular and cellular cardiology. 2012 52:1074-82. (WB; Mouse) [PubMed:22285962] [PMC:PMC3327806]
3
Improved Assay for Quantifying a Redox Form of Angiotensinogen as a Biomarker for Pre-Eclampsia: A Case-Control Study. Rahgozar S, Amirian T, Qi M, Shahshahan Z, Entezar-E-Ghaem M, Ghasemi Tehrani H, Miroliaei M, Krilis SA, Giannakopoulos B. PloS one. 2015 10:e0135905. (WB; Human) [Full Text Article] [PubMed:26312482] [PMC:PMC4552422] Related Antibodies: LS-C80597.
4
Angiotensinogen and HLA class II predict bevacizumab response in recurrent glioblastoma patients. Urup T, Michaelsen SR, Olsen LR, Toft A, Christensen IJ, Grunnet K, Winther O, Broholm H, Kosteljanetz M, Issazadeh-Navikas S, Poulsen HS, Lassen U. Molecular oncology. 2016 October;10:1160-8. (Human) [Full Text Article] [PubMed:27262894] [PMC:PMC5423207] Related Antibodies: LS-B6575.
5
Exploration of cardiometabolic and developmental significance of angiotensinogen expression by cells expressing the leptin receptor or agouti-related peptide. Sarah A Sapouckey, Lisa L Morselli, Guorui Deng, Chetan N Patil, Kirthikaa Balapattabi, Vanessa Oliveira, Kristin E Claflin, Javier Gomez, Nicole A Pearson, Matthew J Potthoff, Katherine N Gibson-Corley, Curt D Sigmund, Justin L Grobe. American journal of physiology. Regulatory, integrative and comparative physiology. 2020 May;318:R855-R869. [Full Text Article] [PubMed:32186897] [PMC:PMC7272763]
6
Persistent Renin-Angiotensin System Sensitization Months After Body Weight Recovery From Severe Food Restriction in Female Fischer Rats. Aline M A de Souza, Hong Ji, Xie Wu, Kathryn Sandberg, Crystal A West. Journal of the American Heart Association. 2020 July;9:e017246. [Full Text Article] [PubMed:32674648] [PMC:PMC7660733]
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AGT / Angiotensinogen (114)
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No (112)
Yes (2)
AGT / Angiotensinogen Antibody - Anti-AGT / Angiotensinogen antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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AGT / Angiotensinogen Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
AGT / Angiotensinogen Antibody - Anti-AGT / Angiotensinogen antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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AGT / Angiotensinogen Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
AGT / Angiotensinogen Antibody - Anti-AGT / Angiotensinogen antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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AGT / Angiotensinogen Rabbit anti-Human Monoclonal (Internal) (EPR2930(2)) Antibody
Human
Flo, ICC, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
AGT / Angiotensinogen Antibody - Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with AGT antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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AGT / Angiotensinogen Rabbit anti-Human Polyclonal (aa37-65) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
AGT / Angiotensinogen Antibody - Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with AGT antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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AGT / Angiotensinogen Rabbit anti-Human Polyclonal (aa418-450) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
AGT / Angiotensinogen Antibody - Fetal heart lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 10-20%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AGT / Angiotensinogen Rabbit anti-Human Polyclonal (aa38-87) Antibody
Human
WB
Unconjugated
100 µl/$424
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AGT / Angiotensinogen Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, WB
Unconjugated
100 µl/$440; 200 µl/$468
AGT / Angiotensinogen Antibody - Western blot using AGT mouse monoclonal antibody against human plasma (1).
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AGT / Angiotensinogen Mouse anti-Human Monoclonal (1B1) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$435
AGT / Angiotensinogen Antibody - Anti-AGT rabbit monoclonal antibody at 1:1000 dilution. Lane A: Mouse spleen tissue lysate. Lane B: Mouse liver tissue lysate. Lane C: Mouse kidney tissue lysate. Lysates/proteins at 30 ug per lane. Secondary: Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 51 kDa.
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AGT / Angiotensinogen Rabbit anti-Mouse Monoclonal (Preservative Free) (001) Antibody
Mouse
WB
Unconjugated, Preservative Free
100 µl/$412
AGT / Angiotensinogen Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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AGT / Angiotensinogen Rabbit anti-Human Polyclonal (aa35-285) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
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AGT / Angiotensinogen Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IF, IP, WB
Unconjugated
100 µl/$412
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AGT / Angiotensinogen Mouse anti-Rat Monoclonal (071505) Antibody
Rat
Unconjugated
200 µl/$660
AGT / Angiotensinogen Antibody - IHC of paraffin-embedded Hepatocellular carcinoma Huh7 xenograft using AGT antibody at 1:100 dilution.
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AGT / Angiotensinogen Rabbit anti-Human Polyclonal (aa1-476) Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$450
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AGT / Angiotensinogen Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$341
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AGT / Angiotensinogen Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$331
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AGT / Angiotensinogen Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
0.2 ml/$386
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AGT / Angiotensinogen Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Biotin Conjugated
0.2 ml/$416
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AGT / Angiotensinogen Rabbit anti-Human Polyclonal (DY550) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
DY550 Conjugated
0.2 ml/$416
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AGT / Angiotensinogen Rabbit anti-Human Polyclonal (DY650) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
DY650 Conjugated
0.2 ml/$416
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AGT / Angiotensinogen Rabbit anti-Human Polyclonal (DY488) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
DY488 Conjugated
0.2 ml/$416
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AGT / Angiotensinogen Mouse anti-Human Monoclonal Antibody
Human
Flo, ICC, IF
Unconjugated
100 µl/$412
AGT / Angiotensinogen Antibody - Immunohistochemistry Dilution at 1:500 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal Goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated Secondary antibody and visualized using an HRP conjugated SP system.
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AGT / Angiotensinogen Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
AGT / Angiotensinogen Antibody - Immunohistochemistry of paraffin-embedded Human breast cancer using AGT Polyclonal Antibody at dilution of 1:30.
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AGT / Angiotensinogen Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
AGT / Angiotensinogen Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using AGT Polyclonal Antibody at dilution of 1:30.
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AGT / Angiotensinogen Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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AGT / Angiotensinogen Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
100 µl/$412
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).