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Unfortunately, the antibody (ID:64446) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



AGRN / Agrin

agrin

Isoform 1: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homestasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release from motor neurons, to basal lamina through binding laminin via the NtA domain.Isoform 2: transmembrane form that is the predominate form in neurons of the brain, induces dendritic filopodia and synapse formation in mature hippocampal neurons in large part due to the attached glycosaminoglycan chains and the action of Rho-family GTPases.Isoform 1, isoform 4 and isoform 5: neuron-specific (z+) isoforms that contain C-terminal insertions of 8-19 AA are potent activators of AChR clustering. Isoform 5, agrin (z+8), containing the 8-AA insert, forms a receptor complex in myotubules containing the neuronal AGRN, the muscle-specific kinase MUSK and LRP4, a member of the LDL receptor family. The splicing factors, NOVA1 and NOVA2, regulate AGRN splicing and production of the 'z' isoforms.Isoform 3 and isoform 6: lack any 'z' insert, are muscle-specific and may be involved in endothelial cell differentiation.Agrin N-terminal 110 kDa subunit: is involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling.

Gene Name: agrin
Synonyms: AGRN, Agrin, Agrin proteoglycan
Target Sequences: NM_198576 AAC39776.1 O00468

Filtered By: None
Target
agrn-agrin (27)
Reactivity
Human (9)
Mouse (19)
Rat (19)
Application
IHC (6)
IHC-Fr (1)
WB (22)
ELISA (13)
ICC (14)
Host
rabbit (15)
mouse (12)
Isotype
IgG (12)
IgG1 (10)
IgG2a (2)
Clonality
monoclonal mc (12)
polyclonal pc (15)
Clone
AGR 131 (1)
Agr247 (1)
Agr-33 (1)
Format
AP Conjugated (1)
APC Conjugated (1)
Biotin Conjugated (4)
FITC Conjugated (4)
HRP Conjugated (1)
PE Conjugated (1)
Unconjugated (15)
Epitope
C-Terminus (6)
aa1130-1401 (3)
aa1206-1475 (3)
aa1856-2045 (3)
N-Terminus (1)
Publications
No (27)
Showing 1-25 out of 27 results
Anti-AGRN / Agrin Antibody (N-Terminus) LS-C137122

Rabbit Polyclonal (IgG) to Human AGRN / Agrin
Mouse, Rat, Human
ELISA IHC
Unconjugated
Anti-AGRN / Agrin Antibody (C-Terminus) LS-C11829

Mouse Monoclonal (IgG2a) to Rat AGRN / Agrin
Mouse, Rat
ICC WB
Unconjugated
Anti-AGRN / Agrin Antibody (C-Terminus, clone Agr-33) LS-C63140

Mouse Monoclonal [clone Agr-33] (IgG1) to Rat AGRN / Agrin
Mouse, Rat
IHC
Unconjugated
Anti-AGRN / Agrin Antibody (C-Terminus, clone Agr247) LS-C63142

Mouse Monoclonal [clone Agr247] (IgG1) to Rat AGRN / Agrin
Mouse, Rat
IHC
Unconjugated
Anti-AGRN / Agrin Antibody LS-C415018

Rabbit Polyclonal to Mouse AGRN / Agrin
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
Anti-AGRN / Agrin Antibody (aa1130-1401, Biotin) LS-C420273

Rabbit Polyclonal (IgG) to Mouse AGRN / Agrin
Mouse
ELISA ICC WB
Biotin Conjugated
Anti-AGRN / Agrin Antibody (aa1130-1401, FITC) LS-C420272

Rabbit Polyclonal (IgG) to Mouse AGRN / Agrin
Mouse
ELISA ICC WB
FITC Conjugated
Anti-AGRN / Agrin Antibody (aa1856-2045, Biotin) LS-C420270

Rabbit Polyclonal (IgG) to Human AGRN / Agrin
Human
ELISA ICC WB
Biotin Conjugated
Anti-AGRN / Agrin Antibody (aa1856-2045, FITC) LS-C420271

Rabbit Polyclonal (IgG) to Human AGRN / Agrin
Human
ELISA ICC WB
FITC Conjugated
Anti-AGRN / Agrin Antibody LS-C402607

Rabbit Polyclonal (IgG) to Human AGRN / Agrin
Human
ELISA IHC
Unconjugated
Anti-AGRN / Agrin Antibody (aa1130-1401) LS-C374094

Rabbit Polyclonal (IgG) to Mouse AGRN / Agrin
Mouse
ELISA WB
Unconjugated
Anti-AGRN / Agrin Antibody LS-C405862

Rabbit Polyclonal (IgG) to Human AGRN / Agrin
Human
ELISA IHC
Unconjugated
Anti-AGRN / Agrin Antibody (aa1856-2045) LS-C314746

Rabbit Polyclonal (IgG) to Human AGRN / Agrin
Human
ELISA WB
Unconjugated
Anti-AGRN / Agrin Antibody (C-Terminus) LS-C11825

Mouse Monoclonal (IgG1) to Rat AGRN / Agrin
Mouse, Rat
ICC WB
Unconjugated
Anti-AGRN / Agrin Antibody (HRP) LS-C543371

Mouse Monoclonal (IgG1) to Rat AGRN / Agrin
Mouse, Rat
ICC WB
HRP Conjugated
Anti-AGRN / Agrin Antibody (Biotin) LS-C523246

Mouse Monoclonal (IgG1) to Rat AGRN / Agrin
Mouse, Rat
ICC WB
Biotin Conjugated
Anti-AGRN / Agrin Antibody (FITC) LS-C533287

Mouse Monoclonal (IgG1) to Rat AGRN / Agrin
Mouse, Rat
ICC WB
FITC Conjugated
Anti-AGRN / Agrin Antibody (APC) LS-C515002

Mouse Monoclonal (IgG1) to Rat AGRN / Agrin
Mouse, Rat
ICC WB
APC Conjugated
Anti-AGRN / Agrin Antibody (AP) LS-C505318

Mouse Monoclonal (IgG1) to Rat AGRN / Agrin
Mouse, Rat
ICC WB
AP Conjugated
Anti-AGRN / Agrin Antibody (PE) LS-C651485

Mouse Monoclonal (IgG1) to Rat AGRN / Agrin
Mouse, Rat
ICC WB
PE Conjugated
Anti-AGRN / Agrin Antibody (aa1206-1475, FITC) LS-C420274

Rabbit Polyclonal (IgG) to Rat AGRN / Agrin
Rat
ELISA ICC WB
FITC Conjugated
Anti-AGRN / Agrin Antibody (aa1206-1475, Biotin) LS-C420275

Rabbit Polyclonal (IgG) to Rat AGRN / Agrin
Rat
ELISA ICC WB
Biotin Conjugated
Anti-AGRN / Agrin Antibody LS-C45609

Mouse Monoclonal (IgG1) to Rat AGRN / Agrin
Mouse, Rat
IHC-Fr WB
Unconjugated
Anti-AGRN / Agrin Antibody (aa1206-1475) LS-C314745

Rabbit Polyclonal (IgG) to Rat AGRN / Agrin
Rat
ELISA WB
Unconjugated
Anti-AGRN / Agrin Antibody LS-C342124

Rabbit Polyclonal to Human AGRN / Agrin
Mouse, Rat, Human
WB
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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