AGER / RAGE

advanced glycosylation end product-specific receptor

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.

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Products

Proteins (15)

Type

Over-Expression Lysate (4)

Recombinant (11)

Target

AGER / RAGE (15)

Publications

No (15)

Tag

6His, C-terminus (2)

GST (1)

GST, N-terminus (1)

His (1)

His,C-terminus (2)

His-T7 (3)

Myc-DDK (Flag) (4)

Species

Human (10)

Mouse (2)

Rat (1)

Source

293T Cells (2)

E. coli (4)

HEK 293 Cells (4)

Human Cells (2)

Mammalian Cells (1)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (5)

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Rat AGER / RAGE Protein (Recombinant His-T7) (aa180-402) - LS-G24074

Source:

E. coli

Tag:

His-T7

Molecular Weight:

27.0 kDa

Price:

10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252

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Human AGER / RAGE Protein (Recombinant His,C-terminus) (Met1-Ala344) - LS-G138026

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

35.5 kDa

Price:

100 µg/$721

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Mouse AGER / RAGE Protein (Recombinant His,C-terminus) (Met1-Ala342) - LS-G138149

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

35.3 kDa

Price:

100 µg/$721

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Human AGER / RAGE Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88729

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

20 µg/$150

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Human AGER / RAGE Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88731

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34 kDa

Price:

20 µg/$150

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AGER / RAGE Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105501

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34 kDa

Price:

100 µg/$494

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Human AGER / RAGE Protein (Recombinant His) (aa23-342) - LS-G22624

Source:

E. coli

Tag:

His

Molecular Weight:

38.1 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human AGER / RAGE Protein (Recombinant GST) (Full Length) - LS-G27393

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

67.76 kDa

Price:

10 µg/$479; 25 µg/$670

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Human AGER / RAGE Protein (Recombinant GST, N-terminus) (aa87-197) - LS-G57728

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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AGER / RAGE Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99343

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

100 µg/$494

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Human AGER / RAGE Protein (Recombinant 6His, C-terminus) (Ala23-Ala344) - LS-G138931

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

35.2 kDa

Price:

10 µg/$269; 50 µg/$368

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Human AGER / RAGE Protein (Recombinant 6His, C-terminus) (Ala23-Ala344) - LS-G38932

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

35.2kD

Price:

10 µg/$269; 50 µg/$372; 500 µg/$1,585; 1 mg/$2,157

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Human AGER / RAGE Protein (Recombinant) (Met1-Ala344) - LS-G97135

Source:

Human Cells

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

35 kDa

Price:

100 µg/$721

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Human AGER / RAGE Protein (Recombinant His-T7) - LS-G12558

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.1 kDa

Price:

10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298

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Mouse AGER / RAGE Protein (Recombinant His-T7) (aa10-188) - LS-G12561

Source:

E. coli

Tag:

His-T7

Molecular Weight:

23.3 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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