AGAP2 / PIKE

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that interacts with nuclear phosphoinositide 3-kinase (PI3 kinase) to stimulate its lipid kinase activity. PIKE exists in multiple isoforms; a shorter C-terminal isoform (PIKE-A) has also been identified as centaurin gamma 1. The longest isoform (PIKE-L) has been shown to bind to the adaptor protein Homer and thereby link to metabotropic glutamate receptors, leading to activation of PI3 kinase activity and prevention of neuronal apoptosis. Overexpression of PIKE-A enhances Akt activity and promotes cancer cell invasion, whereas decreased expression of PIKE-A via dominant negative expression of PIKE-A or PIKE-A knockdown inhibits these processes. In many human cancers, expression of PIKE-A is enhanced, leading to increased Akt activity and preventing apoptosis. Also known as: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2.

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Products

Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

AGAP2 / PIKE (3)

Publications

No (3)

Tag

GST (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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AGAP2 / PIKE Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124428

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

124.4 kDa

Price:

100 µg/$710

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Human AGAP2 / PIKE Protein (Recombinant GST) (Full Length) - LS-G36271

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

116.9 kDa

Price:

10 µg/$479; 25 µg/$670

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Human AGAP2 / PIKE Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80974

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

124.4 kDa

Price:

20 µg/$215

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