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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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AGAP2 / PIKE

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that interacts with nuclear phosphoinositide 3-kinase (PI3 kinase) to stimulate its lipid kinase activity. PIKE exists in multiple isoforms; a shorter C-terminal isoform (PIKE-A) has also been identified as centaurin gamma 1. The longest isoform (PIKE-L) has been shown to bind to the adaptor protein Homer and thereby link to metabotropic glutamate receptors, leading to activation of PI3 kinase activity and prevention of neuronal apoptosis. Overexpression of PIKE-A enhances Akt activity and promotes cancer cell invasion, whereas decreased expression of PIKE-A via dominant negative expression of PIKE-A or PIKE-A knockdown inhibits these processes. In many human cancers, expression of PIKE-A is enhanced, leading to increased Akt activity and preventing apoptosis. Also known as: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2.

Gene Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Family/Subfamily: Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806
Synonyms: AGAP2, AGAP-2, Centaurin, gamma 1, Cnt-g1, Centaurin-gamma-1, KIAA0167, GGAP2, PIKE, CENTG1
Target Sequences: NM_014770 NP_055585.1 Q99490

Filtered By: None
Target
AGAP2 / PIKE (25)
Reactivity
Human (25)
Mouse (18)
Rat (7)
Bat (4)
Bovine (5)
Dog (1)
Gibbon (3)
Guinea pig (1)
Horse (2)
Monkey (6)
Pig (1)
Rabbit (1)
Application
IHC (9)
IHC-P (6)
WB (23)
ELISA (12)
ICC (1)
IF (2)
IP (2)
Peptide-ELISA (1)
Host
rabbit (24)
goat (1)
Isotype
IgG (12)
Clonality
polyclonal pc (25)
Format
AP Conjugated (2)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (15)
Epitope
aa850-877 (8)
aa719-768 (4)
aa450-500 (2)
C-Terminus (1)
Internal (1)
aa1-836 (1)
aa20-60 (1)
aa46-60 (1)
aa700-750 (1)
Publications
No (25)
Showing 1-25 of 25 results

AGAP2 / PIKE Antibody (aa1-836) IHC-plus™ LS-B338
Rabbit Polyclonal to Human AGAP2 / PIKE
Mouse, Human
ELISA IF IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-AGAP2 / PIKE antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-AGAP2 Antibody - Western Blot. Western blot of Protein A purified anti-AGAP2 antibody shows detection of AGAP2 recombinant protein in transfected HEK293 cell lysates. No specific band staining is noted in mock transfected cell lysates (empty vector). The membrane was probed with the primary antibody diluted to 1:10000. Personal Communication, Paul Randazzo, CCR-NCI, Bethesda, MD.
Anti-AGAP2 / PIKE antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-AGAP2 Antibody - Western Blot. Western blot of Protein A purified anti-AGAP2 antibody shows detection of AGAP2 recombinant protein in transfected HEK293 cell lysates. No specific band staining is noted in mock transfected cell lysates (empty vector). The membrane was probed with the primary antibody diluted to 1:10000. Personal Communication, Paul Randazzo, CCR-NCI, Bethesda, MD.

AGAP2 / PIKE Antibody (C-Terminus) IHC-plus™ LS-B134
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Mouse, Human
IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-AGAP2 / PIKE antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
Anti-AGAP2 / PIKE antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.

AGAP2 / PIKE Antibody (aa46-60) IHC-plus™ LS-B4387
Goat Polyclonal to Human AGAP2 / PIKE
Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-AGAP2 / PIKE antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Anti-AGAP2 / PIKE antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Anti-AGAP2 / PIKE antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Anti-AGAP2 / PIKE antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.

AGAP2 / PIKE Antibody (aa850-877) LS-C168676
Rabbit Polyclonal to Human AGAP2 / PIKE
Mouse, Human
WB
Unconjugated
400µl  $305.00
CENTG1 Antibody western blot of mouse brain tissue lysates (35 ug/lane). The CENTG1 antibody detected the CENTG1 protein (arrow).
CENTG1 Antibody western blot of mouse brain tissue lysates (35 ug/lane). The CENTG1 antibody detected the CENTG1 protein (arrow).

AGAP2 / PIKE Antibody LS-C659948
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Human
ELISA IF IHC WB
Unconjugated
100µg  $435.00

AGAP2 / PIKE Antibody LS-C403061
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Human
ELISA IHC WB
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human breast cancer using AGAP2 Polyclonal Antibody at dilution of 1:30.
Immunohistochemistry of Human gastric cancer using AGAP2 Polyclonal Antibody at dilution of 1:30.
Immunohistochemistry of Human breast cancer using AGAP2 Polyclonal Antibody at dilution of 1:30.
Immunohistochemistry of Human gastric cancer using AGAP2 Polyclonal Antibody at dilution of 1:30.

AGAP2 / PIKE Antibody (Internal) LS-C145163
Rabbit Polyclonal to Human AGAP2 / PIKE
Human
ELISA ICC WB
Unconjugated
100µl  $365.00

AGAP2 / PIKE Antibody (aa20-60) LS-C148542
Rabbit Polyclonal to Human AGAP2 / PIKE
Human, Monkey
IHC IHC-P WB
Unconjugated
100µg  $335.00
IHC ofAGAP2 in formalin-fixed, paraffin-embedded human brain tissue using an isotype control (top left) and Peptide-affinity Purified Polyclonal Antibody to AGAP2 (bottom left, right) at 5 ug/ml.
Western blot of AGAP2 in Jurkat cell lysate in the 1) absence and 2) presence of immunizing peptide using Peptide-affinity Purified Polyclonal Antibody to AGAP2 at 2.0 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.
IHC ofAGAP2 in formalin-fixed, paraffin-embedded human brain tissue using an isotype control (top left) and Peptide-affinity Purified Polyclonal Antibody to AGAP2 (bottom left, right) at 5 ug/ml.
Western blot of AGAP2 in Jurkat cell lysate in the 1) absence and 2) presence of immunizing peptide using Peptide-affinity Purified Polyclonal Antibody to AGAP2 at 2.0 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.

AGAP2 / PIKE Antibody (aa450-500) LS-C148580
Rabbit Polyclonal to Human AGAP2 / PIKE
Mouse, Rat, Horse, Human, Monkey
IHC IHC-P WB
Unconjugated
100µg  $335.00
IHC ofAGAP2 in formalin-fixed, paraffin-embedded human brain tissue using an isotype control (top left) and Peptide-affinity Purified Polyclonal Antibody to AGAP2 (bottom left, right) at 5 ug/ml.
Western blot of AGAP2 in Jurkat cell lysate in the 1) absence and 2) presence of immunizing peptide using Peptide-affinity Purified Polyclonal Antibody to AGAP2 at 1 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.
IHC ofAGAP2 in formalin-fixed, paraffin-embedded human brain tissue using an isotype control (top left) and Peptide-affinity Purified Polyclonal Antibody to AGAP2 (bottom left, right) at 5 ug/ml.
Western blot of AGAP2 in Jurkat cell lysate in the 1) absence and 2) presence of immunizing peptide using Peptide-affinity Purified Polyclonal Antibody to AGAP2 at 1 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.

AGAP2 / PIKE Antibody LS-C668191
Rabbit Polyclonal to Human AGAP2 / PIKE
Human
IHC IHC-P WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $275.00
Immunohistochemistry - Paraffin Image
Western blot Image
Immunohistochemistry - Paraffin Image
Western blot Image

AGAP2 / PIKE Antibody LS-C406302
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Human
ELISA IHC
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human thyroid cancer using AGAP2 Polyclonal Antibody at dilution of 1:60.
Immunohistochemistry of Human thyroid cancer using AGAP2 Polyclonal Antibody at dilution of 1:60.

AGAP2 / PIKE Antibody (aa850-877) LS-C320326
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Mouse, Human
ELISA WB
Unconjugated
200µl  $530.00

AGAP2 / PIKE Antibody (aa850-877, Biotin) LS-C254628
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Mouse, Human
ELISA WB
Biotin Conjugated
200µl  $680.00

AGAP2 / PIKE Antibody (aa850-877, FITC) LS-C254629
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Mouse, Human
ELISA WB
FITC Conjugated
200µl  $680.00

AGAP2 / PIKE Antibody (aa850-877, APC) LS-C254627
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Mouse, Human
ELISA WB
APC Conjugated
200µl  $680.00

AGAP2 / PIKE Antibody (aa850-877, Azide-free, HRP) LS-C254630
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Mouse, Human
ELISA WB
HRP Conjugated, Azide-free
200µl  $680.00

AGAP2 / PIKE Antibody (aa850-877, PE) LS-C254633
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Mouse, Human
ELISA WB
PE Conjugated
200µl  $680.00

AGAP2 / PIKE Antibody (aa850-877, AP) LS-C254626
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Mouse, Human
ELISA WB
AP Conjugated
200µl  $680.00

AGAP2 / PIKE Antibody (aa450-500) LS-C290904
Rabbit Polyclonal to Human AGAP2 / PIKE
Rabbit, Mouse, Dog, Guinea pig, Rat, Pig, Horse, Human
IP WB
Unconjugated
100µl 1mg/ml  $395.00
Detection of Human PIKE by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa, 293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-PIKE antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
Detection of Human PIKE by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa, 293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-PIKE antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

AGAP2 / PIKE Antibody (aa719-768) LS-C116484
Rabbit Polyclonal to Human AGAP2 / PIKE
Mouse, Bovine, Rat, Bat, Human, Monkey
WB
Unconjugated
50µg  $365.00
AGAP2 / PIKE antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
AGAP2 / PIKE antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

AGAP2 / PIKE Antibody (aa719-768, HRP) LS-C455952
Rabbit Polyclonal to Human AGAP2 / PIKE
Mouse, Bovine, Rat, Bat, Gibbon, Human, Monkey
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
AGAP2 / PIKE antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
AGAP2 / PIKE antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

AGAP2 / PIKE Antibody (aa719-768, Biotin) LS-C455950
Rabbit Polyclonal to Human AGAP2 / PIKE
Mouse, Bovine, Rat, Bat, Gibbon, Human, Monkey
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
AGAP2 / PIKE antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
AGAP2 / PIKE antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

AGAP2 / PIKE Antibody (aa719-768, FITC) LS-C455951
Rabbit Polyclonal to Human AGAP2 / PIKE
Mouse, Bovine, Rat, Bat, Gibbon, Human, Monkey
WB
FITC Conjugated
100µl 1mg/ml  $385.00
AGAP2 / PIKE antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
AGAP2 / PIKE antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

AGAP2 / PIKE Antibody (aa700-750) LS-C290906
Rabbit Polyclonal to Human AGAP2 / PIKE
Mouse, Bovine, Rat, Human
IP
Unconjugated
100µl 1mg/ml  $395.00

AGAP2 / PIKE Antibody (AP) LS-C410564
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Mouse, Human
WB
AP Conjugated
100µl  $295.00; 200µl  $385.00
Showing 1-25 of 25 results

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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