ADRBK1 / GRK2

adrenergic, beta, receptor kinase 1

Beta-adrenergic receptor kinase (ADRBK1) phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. ADRBK1 is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. The ADRBK1 gene spans approximately 23 kb and is composed of 21 exons. Heart failure is accompanied by severely impaired beta-adrenergic receptor (beta-AR) function. An important mechanism for the rapid desensitization of beta-AR function is agonist-stimulated receptor phosphorylation by the beta-AR kinase (beta-ARK1), an enzyme known to be elevated in failing human heart tissue. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. Inhibition of ADRBK1 is a novel mode of therapy.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

ADRBK1 / GRK2 (8)

Publications

No (8)

Tag

6His-SUMO, N-terminus (1)

GST (1)

His (1)

His-GST (2)

Myc-DDK (Flag) (3)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

Baculovirus (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (1)

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Mouse ADRBK1 / GRK2 Protein (Recombinant 6His-SUMO, N-terminus) (aa1-689) - LS-G57608

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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Human ADRBK1 / GRK2 Protein (Recombinant His) (Full Length) - LS-G22082

Source:

E. coli

Tag:

His

Molecular Weight:

29.7 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human ADRBK1 / GRK2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69756

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

79.4 kDa

Price:

20 µg/$1,107

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Human ADRBK1 / GRK2 Protein (Recombinant His-GST) (Met1-Leu689) - LS-G97132

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

107 kDa

Price:

50 µg/$502

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Human ADRBK1 / GRK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85476

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

79.4 kDa

Price:

20 µg/$150

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Human ADRBK1 / GRK2 Protein (Recombinant His-GST) (aa398-640) - LS-G14838

Source:

E. coli

Tag:

His-GST

Molecular Weight:

60.7 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human ADRBK1 / GRK2 Protein (Recombinant GST) (Full Length) - LS-G27378

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

106 kDa

Price:

10 µg/$479; 25 µg/$670

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ADRBK1 / GRK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118491

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

79.4 kDa

Price:

100 µg/$494

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