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ADRB2

adrenoceptor beta 2, surface

ADRB2 is beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.

Gene Name: adrenoceptor beta 2, surface
Family/Subfamily: GPCR , Adrenergic
Synonyms: ADRB2, ADRB2R, Adrenoceptor beta 2, surface, ADRBR, B2AR, Beta-2 adrenoceptor, Beta-2 adrenergic receptor, Beta-2 adrenoreceptor, BETA2AR, BAR, Adrenergic beta-2 receptor, Catecholamine receptor
Target Sequences: NM_000024 NP_000015.1 P07550

Publications (4)

1
Matrix metalloproteinases cleave the beta2-adrenergic receptor in spontaneously hypertensive rats. Rodrigues SF, Tran ED, Fortes ZB, Schmid-Schnbein GW. American journal of physiology. Heart and circulatory physiology. 2010 299:H25-35. [PubMed:20382857] [PMC:PMC2904131]
2
ß-Adrenergic receptor subtype expression in myocyte and non-myocyte cells in human female bladder. Limberg BJ, Andersson KE, Aura Kullmann F, Burmer G, de Groat WC, Rosenbaum JS. Cell and tissue research. 2011 317:107-16. (ICC, IHC-P; Human) [Full Text Article] [PubMed:20953633] [PMC:PMC3113530] Related Antibodies: LS-A2662.
3
Flow Cytometry of Mouse and Human Adipocytes for the Analysis of Browning and Cellular Heterogeneity. Hagberg CE, Li Q, Kutschke M, Bhowmick D, Kiss E, Shabalina IG, Harms MJ, Shilkova O, Kozina V, Nedergaard J, Boucher J, Thorell A, Spalding KL. Cell reports. 2018 September;24:2746-2756. [Full Text Article] [PubMed:30184507] [PMC:PMC6137819] Related Antibodies: LS-C274967.
4
Clenbuterol and formoterol decrease force production in isolated intact mouse skeletal muscle fiber bundles through a beta2-adrenoceptor-independent mechanism. McCormick C, Alexandre L, Thompson J, Mutungi G. Journal of applied physiology (Bethesda, Md. : 1985). 2010 Dec;109:1716-27. [Full Text Article] [PubMed:20864554] Related Antibodies: LS-C54456.
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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
ADRB2 (4)
No (4)
6His-SUMO, N-terminus (1)
GST (1)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (2)
ADRB2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
100 µg/$1,801; 20 µg/$1,247
ADRB2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
46.4 kDa
20 µg/$150
ADRB2 Protein - 12.5% SDS-PAGE of human ADRB2 stained with Coomassie Blue
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Wheat Germ Extract
GST
73 kDa
2 µg/$439
ADRB2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
46.4 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).