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ADRA2A

adrenoceptor alpha 2A

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences.

Gene Name: adrenoceptor alpha 2A
Family/Subfamily: GPCR , Adrenergic
Synonyms: ADRA2A, Alpha-2A adrenoreceptor, Alpha-2AAR, Alpha-2AAR subtype C10, ADRA2, ADRA2R, ADRAR, Adrenoceptor alpha 2A, Alpha 2a, Alpha(2A)-AR, Alpha2a, ALPHA2AAR, Alpha-2A adrenoceptor, Adrenergic alpha 2a receptor, Adrenergic alpha 2a receptor, Alpha-2A adrenergic receptor
Target Sequences: NM_000681 NP_000672.3 P08913

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ADRA2A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
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48.8 kDa
100 µg/$494
ADRA2A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
48.8 kDa
20 µg/$150
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).