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ADPRHL2

ADP-ribosylhydrolase like 2

Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria.

Gene Name:	ADP-ribosylhydrolase like 2
Synonyms:	ADPRHL2, ADP-ribosylhydrolase like 2, ARH3, ADP-ribosylhydrolase 3
Target Sequences:	NM_017825 NP_060295.1 Q9NX46

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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