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ADORA2B/Adenosine A2B Receptor

adenosine A2b receptor

The A2b Adenosine Receptor is a target of theophylline and enprofylline in the treatment of asthma. In lung mast cells, A2b receptors are associated with the release of inflammatory mediators. They can also bind the axonal chemoattractant netrin-1 (Corset et al., 2000). Netrin-1-dependent outgrowth of axons in the dorsal spinal cord directly involves the adenosine A2b receptor and may involve a receptor complex containing the DCC (deleted in colorectal cancer) protein and adenosine A2b receptor.

Gene Name: adenosine A2b receptor
Family/Subfamily: GPCR , Adenosine
Synonyms: ADORA2B, ADORA2, A2b receptor, Adenosine A2b receptor, Adenosine a2b, Adenosine receptor A2b, A2b adenosine receptor
Target Sequences: NM_000676 NP_000667.1 P29275

Publications (2)

1
MiR-27b regulates podocyte survival through targeting adenosine receptor 2B in podocytes from non-human primate. Zheng Z, Hu H, Tong Y, Hu Z, Cao S, Shan C, Lin W, Yin Y, Li Z. Cell death & disease. 2018 November;9:1133. [Full Text Article] [PubMed:30429458] [PMC:PMC6235956] Related Antibodies: LS-A680.
2
Anti-Inflammatory Effects of Endogenously Released Adenosine in Synovial Cells of Osteoarthritis and Rheumatoid Arthritis Patients. Rebecca Sohn, Marius Junker, Andrea Meurer, Frank Zaucke, Rainer H Straub, Zsuzsa Jenei-Lanzl. International journal of molecular sciences. 2021 Aug;22:8956. [Full Text Article] [PubMed:34445661] [PMC:PMC8396606] Related Antibodies: LS-C20310.

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).