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ADH1A / Alcohol Dehydrogenase
alcohol dehydrogenase 1A (class I), alpha polypeptide
ADH1A / Alcohol Dehydrogenase encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence.
| Gene Name: | alcohol dehydrogenase 1A (class I), alpha polypeptide |
| Synonyms: | ADH1A, ADH1, ADH, alpha subunit, Aldehyde reductase, Alcohol dehydrogenase, Alcohol dehydrogenase 1A |
| Target Sequences: | NM_000667 NP_000658.1 P07327 |
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