ADD2

adducin 2 (beta)

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described.

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Proteins (10)

Type

Over-Expression Lysate (6)

Recombinant (4)

Target

ADD2 (10)

Publications

No (10)

Tag

GST (1)

Myc-DDK (Flag) (9)

Species

Human (7)

Source

293T Cells (3)

HEK 293 Cells (6)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human ADD2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65556

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.7 kDa

Price:

20 µg/$1,107

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Human ADD2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65558

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

62.3 kDa

Price:

20 µg/$1,107

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Human ADD2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65559

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72.5 kDa

Price:

20 µg/$1,107

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Human ADD2 Protein (Recombinant GST) (Full Length) - LS-G27364

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

107.2 kDa

Price:

2 µg/$439

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ADD2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112438

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

62.3 kDa

Price:

100 µg/$710

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ADD2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112443

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72.5 kDa

Price:

100 µg/$494

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Human ADD2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75796

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.7 kDa

Price:

20 µg/$150

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Human ADD2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75798

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

62.3 kDa

Price:

20 µg/$215

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Human ADD2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75799

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72.5 kDa

Price:

20 µg/$150

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ADD2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118498

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.7 kDa

Price:

100 µg/$494

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