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ADCYAP1R1 / PAC1 Receptor

adenylate cyclase activating polypeptide 1 (pituitary) receptor type I

The PACAP receptor type 1, a member of the vasoactive intestinal polypeptide subfamily, binds the hormone pituitary adenylate cyclase activating polypeptide (PACAP) with high affinity. PACAP is involved in stimulating the secretion of insulin, catecholamines, ACTH, and growth hormone. Additionally, PACAP appears to function as a neuromodulator/neurotransmitter in the central and peripheral nervous systems. Two start codons are reported in literature, one (nt 74-76) results in a 525-amino acid protein with a signal peptide of 77 amino acids encoded by nt 74-304 and the second (nt 245-247) initiates a 468-amino acid protein with a signal peptide of 20-amino acids encoded by nt 245-304. The efficiency of these two start codons is not known.

Gene Name: adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
Family/Subfamily: GPCR , Vasoactive intestinal polypeptide
Synonyms: ADCYAP1R1, PAC1, Pac1 receptor, Pac1 receptors, PAC1-R, PACAP receptor 1, Pacap specific receptor, PACAP-R-1, PACAP/VIP receptors, PACAP1 receptor, PACAP Receptor, Pacap receptor type 1, Pacap type 1 receptor, PACAP type I receptor, PACAPR, PAC1R, PACAP-R1, PACAPRI, Pvr1, Pacap receptor type i
Target Sequences: NM_001118 NP_001109.2 P41586

Publications (1)

1
The Potential of Asiatic Acid in the Reversion of Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats. Andrzej Wróbel, Lukasz Zapala, Tomasz Kluz, Artur Rogowski, Marcin Misiek, Kajetan Juszczak, Jacek Sienko, Daniela Gold, Klaudia Stangel-Wójcikiewicz, Ewa Poleszak, Piotr Radziszewski. International journal of molecular sciences. 2021 May;22: [Full Text Article] [PubMed:34072606] [PMC:PMC8198845]

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Proteins (3)
Recombinant (3)
ADCYAP1R1 / PAC1 Receptor (3)
SDS-PAGE (1)
No (3)
Fc (1)
GST, N-terminus (1)
Human IgG Fc, C-terminus (1)
Human (3)
HEK 293 Cells (1)
Human Cells (1)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (2)
ADCYAP1R1 / PAC1 Receptor Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ADCYAP1R1 / PAC1 Receptor Protein
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HEK 293 Cells
Human IgG Fc, C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human ADCYAP1R1/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 373 amino acids and has a predicted molecular mass of 42 kDa. The reduced monomer migrates as an approximately 65 kDa band in SDS-PAGE under reducing conditions due to glycosylation.
50 µg/$441
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Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
42 kDa
50 µg/$721
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).