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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ADAM8

ADAM metallopeptidase domain 8

ADAM8 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants.

Gene Name: ADAM metallopeptidase domain 8
Family/Subfamily: Protease , Metallopeptidase M12B
Synonyms: ADAM8, ADAM metallopeptidase domain 8, Cell surface antigen MS2, ADAM 8, MS2, CD156, CD156a antigen
Target Sequences: NM_001109 NP_001100.3 P78325

Publications (3)

1
N-glycosylation regulates ADAM8 processing and activation. Srinivasan S, Romagnoli M, Bohm A, Sonenshein GE. The Journal of biological chemistry. 2014 289:33676-88. (WB; Human) [Full Text Article] [PubMed:25336660] [PMC:PMC4246118] Related Antibodies: LS-B4068.
2
miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells. Das SG, Romagnoli M, Mineva ND, Barillé-Nion S, Jézéquel P, Campone M, Sonenshein GE. Breast cancer research : BCR. 2016 18:40. (WB; Human) [Full Text Article] [PubMed:27039296] [PMC:PMC4818899] Related Antibodies: LS-B4068.
3
ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis. Romagnoli M, Mineva ND, Polmear M, Conrad C, Srinivasan S, Loussouarn D, Barillé-Nion S, Georgakoudi I, Dagg Á, McDermott EW, Duffy MJ, McGowan PM, Schlomann U, Parsons M, Bartsch JW, Sonenshein GE. EMBO molecular medicine. 2014 Feb;6:278-294. (IHC; Human) [Full Text Article] [PubMed:24375628] [PMC:PMC3927960] Related Antibodies: LS-B4068.

Filtered By: None
Type
Over-Expression Lysate (4)
Recombinant (2)
Target
ADAM8 (6)
Tag
His + T7 (2)
Myc + DDK (4)
Species
Human (2)
Mouse (1)
Source
293T Cells (1)
E. coli (2)
HEK 293 Cells (3)
Purification
Purified (2)
Showing 1-6 of 6 results

ADAM8 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G118778
HEK 293 Cells
876 AA
Myc + DDK
88.8 kDa
100µg  $475.00

ADAM8 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G128340
HEK 293 Cells
785 AA
Myc + DDK
78.7 kDa
100µg  $475.00

ADAM8 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G128345
HEK 293 Cells
794 AA
Myc + DDK
80.1 kDa
100µg  $475.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human ADAM8 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G75131
293T Cells
794 AA
Myc + DDK
80.1 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human ADAM8 Protein (Recombinant His + T7) (aa371-587) - LS-G12502
E. coli
His + T7
27.2 kDa
10µg  $295.00; 50µg  $495.00; 100µg  $680.00; 200µg  $995.00; 1mg  $2,580.00
Recombinant A Disintegrin And Metalloprotease 8 By SDS-PAGE

Mouse ADAM8 Protein (Recombinant His + T7) (aa145-493) - LS-G12503
E. coli
His + T7
42.5 kDa
10µg  $285.00; 50µg  $465.00; 100µg  $635.00; 200µg  $920.00; 1mg  $2,370.00
Recombinant A Disintegrin And Metalloprotease 8 By SDS-PAGE
Showing 1-6 of 6 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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