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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ADAM8

ADAM metallopeptidase domain 8

ADAM8 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants.

Gene Name: ADAM metallopeptidase domain 8
Family/Subfamily: Protease , Metallopeptidase M12B
Synonyms: ADAM8, ADAM metallopeptidase domain 8, Cell surface antigen MS2, ADAM 8, MS2, CD156, CD156a antigen
Target Sequences: NM_001109 NP_001100.3 P78325

Publications (3)

1
N-glycosylation regulates ADAM8 processing and activation. Srinivasan S, Romagnoli M, Bohm A, Sonenshein GE. The Journal of biological chemistry. 2014 289:33676-88. (WB; Human) [Full Text Article] [PubMed:25336660] [PMC:PMC4246118] Related Antibodies: LS-B4068.
2
miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells. Das SG, Romagnoli M, Mineva ND, Barillé-Nion S, Jézéquel P, Campone M, Sonenshein GE. Breast cancer research : BCR. 2016 18:40. (WB; Human) [Full Text Article] [PubMed:27039296] [PMC:PMC4818899] Related Antibodies: LS-B4068.
3
ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis. Romagnoli M, Mineva ND, Polmear M, Conrad C, Srinivasan S, Loussouarn D, Barillé-Nion S, Georgakoudi I, Dagg Á, McDermott EW, Duffy MJ, McGowan PM, Schlomann U, Parsons M, Bartsch JW, Sonenshein GE. EMBO molecular medicine. 2014 Feb;6:278-294. (IHC; Human) [Full Text Article] [PubMed:24375628] [PMC:PMC3927960] Related Antibodies: LS-B4068.

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Type
Competitive EIA (2)
Custom (6)
Sandwich (9)
Sandwich CLIA (1)
Target
ADAM8 (18)
Reactivity
Human (8)
Mouse (4)
Rat (1)
Chicken (1)
Monkey (1)
Porcine (1)
Rabbit (1)
Sheep (1)
Sample Type
Cell Culture Supernatants (2)
Cell Lysates (1)
Plasma (10)
Serum (12)
Tissue Homogenates (4)
Publications
No (18)
Showing 1-18 of 18 results

Human ADAM8 ELISA Kit (Sandwich ELISA) - LS-F10745
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate  $700.00
LSBio image for ELISA Kit

Human ADAM8 ELISA Kit (Sandwich ELISA) - LS-F23769
Sandwich
96-Well Microplate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate  $590.00
LSBio image for ELISA Kit

Human ADAM8 ELISA Kit (Sandwich ELISA) - LS-F26687
Sandwich
96-Well Strip Plate
Human
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate  $870.00
LSBio image for ELISA Kit

Mouse ADAM8 ELISA Kit (Custom ELISA) - LS-F14915
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1plate  $700.00
LSBio image for ELISA Kit

Human ADAM8 ELISA Kit (CLIA) - LS-F29260
Sandwich CLIA
12 x 8-Well Microstrips
Human
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1plate  $700.00
LSBio image for ELISA Kit

Mouse ADAM8 ELISA Kit (Competitive EIA) - LS-F28200
Competitive EIA
96-Well Strip Plate
Mouse
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate  $870.00
LSBio image for ELISA Kit

Human ADAM8 ELISA Kit (Sandwich ELISA) - LS-F39704
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Serum
1plate  $530.00
LSBio image for ELISA Kit

Chicken ADAM8 ELISA Kit (Custom ELISA) - LS-F40692
Custom
96-Well Strip Plate
Chicken
3.125 - 200 pg/ml
Colorimetric - 450nm (TMB)
1plate  $660.00
LSBio image for ELISA Kit

Sheep ADAM8 ELISA Kit (Custom ELISA) - LS-F40699
Custom
96-Well Strip Plate
Sheep
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1plate  $730.00
LSBio image for ELISA Kit

Porcine ADAM8 ELISA Kit (Custom ELISA) - LS-F40694
Custom
96-Well Strip Plate
Porcine
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1plate  $660.00
LSBio image for ELISA Kit

Monkey ADAM8 ELISA Kit (Custom ELISA) - LS-F40693
Custom
96-Well Strip Plate
Monkey
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1plate  $660.00
LSBio image for ELISA Kit

Rabbit ADAM8 ELISA Kit (Custom ELISA) - LS-F40695
Custom
96-Well Strip Plate
Rabbit
2.5 - 160 pg/ml
Colorimetric - 450nm (TMB)
1plate  $660.00
LSBio image for ELISA Kit

Human ADAM8 ELISA Kit (Sandwich ELISA) - LS-F35464
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1plate  $790.00
LSBio image for ELISA Kit

Mouse ADAM8 ELISA Kit (Sandwich ELISA) - LS-F52877
Sandwich
96-Well Strip Plate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1plate  $870.00
LSBio image for ELISA Kit

Rat ADAM8 ELISA Kit (Competitive EIA) - LS-F27874
Competitive EIA
96-Well Strip Plate
Rat
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1plate  $870.00
LSBio image for ELISA Kit

Human ADAM8 ELISA Kit (Sandwich ELISA) - LS-F4347
Sandwich
96-Well Strip Plate
Human
6.25 - 400 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1plate  $700.00
LSBio image for ELISA Kit

Mouse ADAM8 ELISA Kit (Sandwich ELISA) - LS-F4348
Sandwich
96-Well Strip Plate
Mouse
7.81 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1plate  $610.00
LSBio image for ELISA Kit

Human ADAM8 ELISA Kit (Sandwich ELISA) - LS-F31615
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Serum
1plate  $620.00
LSBio image for ELISA Kit
Showing 1-18 of 18 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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