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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ADAM8

ADAM metallopeptidase domain 8

ADAM8 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants.

Gene Name: ADAM metallopeptidase domain 8
Family/Subfamily: Protease , Metallopeptidase M12B
Synonyms: ADAM8, ADAM metallopeptidase domain 8, Cell surface antigen MS2, ADAM 8, MS2, CD156, CD156a antigen
Target Sequences: NM_001109 NP_001100.3 P78325

Publications (3)

1
N-glycosylation regulates ADAM8 processing and activation. Srinivasan S, Romagnoli M, Bohm A, Sonenshein GE. The Journal of biological chemistry. 2014 289:33676-88. (WB; Human) [Full Text Article] [PubMed:25336660] [PMC:PMC4246118] Related Antibodies: LS-B4068.
2
miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells. Das SG, Romagnoli M, Mineva ND, Barillé-Nion S, Jézéquel P, Campone M, Sonenshein GE. Breast cancer research : BCR. 2016 18:40. (WB; Human) [Full Text Article] [PubMed:27039296] [PMC:PMC4818899] Related Antibodies: LS-B4068.
3
ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis. Romagnoli M, Mineva ND, Polmear M, Conrad C, Srinivasan S, Loussouarn D, Barillé-Nion S, Georgakoudi I, Dagg Á, McDermott EW, Duffy MJ, McGowan PM, Schlomann U, Parsons M, Bartsch JW, Sonenshein GE. EMBO molecular medicine. 2014 Feb;6:278-294. (IHC; Human) [Full Text Article] [PubMed:24375628] [PMC:PMC3927960] Related Antibodies: LS-B4068.

Filtered by: None
Target
ADAM8 (44)
Reactivity
Human (44)
Mouse (14)
Rat (2)
Monkey (4)
Application
IHC (8)
IHC-P (7)
WB (40)
Flo (1)
ELISA (10)
IF (2)
IP (2)
Peptide-ELISA (1)
Host
rabbit (40)
mouse (2)
goat (2)
Isotype
IgG (16)
IgG1 (1)
IgG2b (1)
Clonality
monoclonal mc (2)
polyclonal pc (42)
Format
AP Conjugated (1)
APC (2)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (6)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (3)
Unconjugated (17)
Epitope
aa126-155 (8)
aa145-493 (8)
aa371-587 (8)
aa70-119 (4)
aa158-653 (2)
Internal (1)
aa813-824 (1)
Publications
No (43)
Yes (1)
Showing 1-25 of 44 results

ADAM8 Antibody IHC-plus™ LS-B4068
Publications (3)
Publications (3)
Rabbit Polyclonal to Human ADAM8
Human
IHC IHC-P WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-ADAM8 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
Anti-ADAM8 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.

ADAM8 Antibody (aa813-824) LS-C20181
Goat Polyclonal to Human ADAM8
Human
Peptide-ELISA WB
Unconjugated
100µg 0.5mg/ml  $405.00
Staining (2 ug/ml) of Human Brain lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by chemiluminescence.
Goat Anti-MS2  / ADAM8 / CD156 Antibody (1µg/ml) staining of Human Bone Marrow lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescencence.

ADAM8 Antibody (aa371-587) IHC-plus™ LS-B15020
Rabbit Polyclonal to Human ADAM8
Human
IHC IHC-P WB
Unconjugated
100µl 0.5mg/ml  $425.00
Western blot of recombinant ADAM8.

ADAM8 Antibody (aa158-653) LS-C124899
Mouse Monoclonal (IgG1) to Human ADAM8
Human
ELISA Flo IP WB
Unconjugated
500µg  $815.00

ADAM8 Antibody (aa145-493) IHC-plus™ LS-B15021
Rabbit Polyclonal to Mouse ADAM8
Mouse, Human
IHC IHC-P WB
Unconjugated
100µl 0.5mg/ml  $425.00
Western blot of recombinant ADAM8.
Western Blot; Sample: Lane1: Human Raji Cells; Lane2: Human Raw264.7 Cells; Lane3: Human 293T Cells; Lane4: Mouse Pancreas Tissue.

ADAM8 Antibody LS-C411876
Rabbit Polyclonal to Human ADAM8
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
100µl 1mg/ml  $385.00
Immunohistochemistry (IHC) analysis of ADAM8 antibody in paraffin-embedded human breast carcinoma tissue at 1:50, showing cytoplasm staining. Negative control (the right) using PBS instead of primary antibody. Secondary antibody is Goat Anti-Rabbit IgG-biotin.
Western blot of ADAM8 antibody at 1:500 dilution. Lane 1: HEK293T whole cell lysate. Lane 2: PC12 whole cell lysate.

ADAM8 Antibody (aa126-155) LS-C319329
Rabbit Polyclonal (IgG) to Human ADAM8
Human
WB
Unconjugated
200µl  $590.00

ADAM8 Antibody (aa126-155, Biotin) LS-C250842
Rabbit Polyclonal (IgG) to Human ADAM8
Human
ELISA WB
Biotin Conjugated
200µl  $740.00

ADAM8 Antibody (aa126-155, FITC) LS-C250841
Rabbit Polyclonal (IgG) to Human ADAM8
Human
ELISA WB
FITC Conjugated
200µl  $740.00

ADAM8 Antibody (aa126-155, AP) LS-C250839
Rabbit Polyclonal (IgG) to Human ADAM8
Human
ELISA WB
AP Conjugated
200µl  $740.00

ADAM8 Antibody (aa126-155, APC) LS-C250840
Rabbit Polyclonal (IgG) to Human ADAM8
Human
ELISA WB
APC Conjugated
200µl  $740.00

ADAM8 Antibody (aa126-155, Azide-free, HRP) LS-C250843
Rabbit Polyclonal (IgG) to Human ADAM8
Human
ELISA WB
HRP Conjugated, Azide-free
200µl  $740.00

ADAM8 Antibody (aa126-155, PE) LS-C250844
Rabbit Polyclonal (IgG) to Human ADAM8
Human
ELISA WB
PE Conjugated
200µl  $740.00

ADAM8 Antibody LS-C669873
Rabbit Polyclonal (IgG) to Human ADAM8
Human
ELISA IF IHC IHC-P WB
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

ADAM8 Antibody (aa126-155) LS-C156046
Rabbit Polyclonal to Human ADAM8
Human
WB
Unconjugated
400µl  $325.00
ADAM8 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The ADAM8 antibody detected the ADAM8 protein (arrow).

ADAM8 Antibody (aa70-119) LS-C135666
Rabbit Polyclonal to Human ADAM8
Mouse, Human, Monkey
WB
Unconjugated
100µl 0.5mg/ml  $365.00
ADAM8 antibody Western blot of PANC1 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

ADAM8 Antibody (aa145-493, FITC) LS-C691112
Rabbit Polyclonal to Mouse ADAM8
Mouse, Human
WB
FITC Conjugated
100µl 0.5mg/ml  $265.00; 200µl 0.5mg/ml  $315.00; 1ml 0.5mg/ml  $575.00
Western blot of recombinant ADAM8.
Western Blot; Sample: Lane1: Human Raji Cells; Lane2: Human Raw264.7 Cells; Lane3: Human 293T Cells; Lane4: Mouse Pancreas Tissue.

ADAM8 Antibody (aa145-493, Cy3) LS-C698841
Rabbit Polyclonal to Mouse ADAM8
Mouse, Human
WB
Cy3 Conjugated
100µl 0.1mg/ml  $345.00; 200µl 0.1mg/ml  $415.00; 1ml 0.1mg/ml  $965.00
Western blot of recombinant ADAM8.
Western Blot; Sample: Lane1: Human Raji Cells; Lane2: Human Raw264.7 Cells; Lane3: Human 293T Cells; Lane4: Mouse Pancreas Tissue.

ADAM8 Antibody IHC-plus™ LS-B15591
Rabbit Polyclonal (IgG) to Human ADAM8
Mouse, Human
IHC IHC-P WB
Unconjugated
50µl  $425.00
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Western blot analysis of extracts of various cell lines, using ADAM8 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 30s.

ADAM8 Antibody LS-C659621
Rabbit Polyclonal (IgG) to Human ADAM8
Human
ELISA IHC WB
Unconjugated
100µg  $405.00

ADAM8 Antibody (aa158-653) LS-C124898
Mouse Monoclonal (IgG2b) to Human ADAM8
Human
ELISA IP WB
Unconjugated
100µg  $680.00; 500µg  $1,410.00

ADAM8 Antibody LS-C749994
Rabbit Polyclonal (IgG) to Human ADAM8
Human
IF WB
Unconjugated
50µl  $235.00; 100µl  $295.00; 200µl  $385.00
Immunofluorescence analysis of HeLa cells using ADAM8 antibody at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

ADAM8 Antibody LS-C484252
Rabbit Polyclonal to Human ADAM8
Human
IHC IHC-P
Unconjugated
50µl  $255.00; 100µl  $305.00; 200µl  $355.00

ADAM8 Antibody LS-C411113
Rabbit Polyclonal (IgG) to Human ADAM8
Human
WB
Unconjugated
100µl  $295.00; 200µl  $385.00

ADAM8 Antibody (Internal) LS-C354312
Rabbit Polyclonal to Human ADAM8
Rat, Human
WB
Unconjugated
100µl 1mg/ml  $245.00
Western blot analysis of CD156a expression in HEK293T (A); PC12 (B) whole cell lysates.
Showing 1-25 of 44 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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