ADAM17 / TACE

ADAM metallopeptidase domain 17

Tumor-necrosis factor-a is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-a is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-a. TNF-a converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFa, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association. ADAM17 is a Metallopeptidase M12B type protease.

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Proteins (3)

Type

Recombinant (3)

Target

ADAM17 / TACE (3)

Product Group

Coronavirus Antibodies Proteins cDNAs (3)

SARS-CoV-2 Associated Proteins (3)

Publications

No (3)

Tag

6His, N-terminus (1)

GST, N-terminus (1)

His (1)

Species

Human (2)

Rat (1)

Source

E. coli (2)

Wheat Germ Extract (1)

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Human ADAM17 / TACE Protein (Recombinant 6His, N-terminus) (aa226-473) - LS-G13997

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

29.5 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human ADAM17 / TACE Protein (Recombinant GST, N-terminus) (aa215-314) - LS-G60268

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Rat ADAM17 / TACE Protein (Recombinant His) (aa221-451) - LS-G24358

Source:

E. coli

Tag:

His

Molecular Weight:

29.6 kDa

Price:

10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252

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