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ACY1 / Aminoacylase 1

aminoacylase 1

ACY1 / Aminoacylase 1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.

Gene Name: aminoacylase 1
Family/Subfamily: Protease , Metallopeptidase M20
Synonyms: ACY1, Aminoacylase-1, ACY-1, ACY1D, Acylase, Acylase I, Aminoacylase 1, Aminoacylase, Aminoacylase I
Target Sequences: NM_000666 NP_000657.1 Q03154

☰ Filters
Products
Proteins (18)
Over-Expression Lysate (8)
Recombinant (10)
ACY1 / Aminoacylase 1 (18)
No (18)
6His, N-terminus (1)
DDK,C-terminus (1)
GST (1)
GST, N-terminus (1)
His (4)
His-S (1)
Myc-DDK (Flag) (9)
Human (12)
Mouse (2)
293T Cells (4)
Baculovirus (1)
E. coli (5)
HEK 293 Cells (5)
Human Cells (1)
Sf9 Cells (1)
Wheat Germ Extract (1)
Purified (4)
Low endotoxin level (2)
ACY1 / Aminoacylase 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
45.7 kDa
100 µg/$494
ACY1 / Aminoacylase 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
38 kDa
100 µg/$494
ACY1 / Aminoacylase 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
39.1 kDa
100 µg/$494
ACY1 / Aminoacylase 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
42.6 kDa
100 µg/$494
ACY1 / Aminoacylase 1 Protein
Select
Sf9 Cells
DDK,C-terminus
45.7 kDa
20 µg/$677
ACY1 / Aminoacylase 1 Protein - Recombinant  Aminoacylase 1 By SDS-PAGE
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E. coli
His-S
49.5 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
ACY1 / Aminoacylase 1 Protein - 12.5% SDS-PAGE of human ACY1 stained with Coomassie Blue
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Wheat Germ Extract
GST
70.62 kDa
10 µg/$479; 25 µg/$670
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293T Cells
Myc-DDK (Flag)
45.7 kDa
20 µg/$150
ACY1 / Aminoacylase 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
39.1 kDa
20 µg/$150
ACY1 / Aminoacylase 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
42.6 kDa
20 µg/$150
ACY1 / Aminoacylase 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
38 kDa
20 µg/$150
ACY1 / Aminoacylase 1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
ACY1 / Aminoacylase 1 Protein - Purified recombinant protein ACY1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
45.7 kDa
20 µg/$1,107
ACY1 / Aminoacylase 1 Protein
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E. coli
His
20 µg/$361; 100 µg/$739; 4 µg/$261
ACY1 / Aminoacylase 1 Protein
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E. coli
His
50 µg/$411; 250 µg/$985; 10 µg/$276
Select
Baculovirus
His
Less than 1.0 EU/µg protein (determined by LAL method).
47.3 kDa
50 µg/$721
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
45 kDa
50 µg/$721
ACY1 / Aminoacylase 1 Protein
Select
E. coli
6His, N-terminus
48 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Viewing 1-18 of 18 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).