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ACVR2 / ACVR2A

activin A receptor, type IIA

ACVR2 / ACVR2A is a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.

Gene Name: activin A receptor, type IIA
Family/Subfamily: Protein Kinase , Activin/TGFb
Synonyms: ACVR2A, ACTRIIA, Activin receptor type IIA, ACTRII, Activin A receptor type II, Activin receptor type-2A, ACTR-IIA, Activin A receptor, type II, Activin A receptor, type IIA, ACVR2
Target Sequences: NM_001616 NP_001607.1 P27037

Publications (1)

1
Detection of Sotatercept (ACE-011) in human serum by SAR-PAGE and western single blotting. Christian Reichel, Letizia Farmer, Günter Gmeiner, Katja Walpurgis, Mario Thevis. Drug testing and analysis. 2018 June;10:927-937. [Full Text Article] [PubMed:29193906]

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ACVR2 / ACVR2A (8)
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Tissue Homogenates (2)
ACVR2 / ACVR2A ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ACVR2 / ACVR2A ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
ACVR2 / ACVR2A ELISA Kit
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Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$929
ACVR2 / ACVR2A ELISA Kit
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Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$783
ACVR2 / ACVR2A ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
ACVR2 / ACVR2A ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
ACVR2 / ACVR2A ELISA Kit
Select
Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1 Plate/$588
ACVR2 / ACVR2A ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).