ACVR1B / ALK4

activin A receptor, type IB

Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.

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Products

Proteins (14)

Type

Over-Expression Lysate (2)

Recombinant (12)

Target

ACVR1B / ALK4 (14)

Publications

No (14)

Tag

6His, C-terminus (3)

6His, N-terminus (1)

Fc, C-terminus (3)

GST (1)

GST, N-terminus (1)

GST, N-terminus + His, C-terminus (1)

His (2)

Myc-DDK (Flag) (2)

Species

Human (9)

Mouse (3)

Rat (1)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (2)

Human Cells (2)

Mammalian Cells (3)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (6)

Biologically Active

Biologically active (1)

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Human ACVR1B / ALK4 Protein (Recombinant His) (aa24-126) - LS-G14764

Source:

E. coli

Tag:

His

Molecular Weight:

12.9 kDa

Price:

10 µg/$273; 50 µg/$390; 100 µg/$622; 200 µg/$777; 1 mg/$1,840; 500 µg/$1,398; 5 mg/$2,801; 2 mg/$2,023

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Human ACVR1B / ALK4 Protein (Recombinant GST, N-terminus + His, C-terminus) - LS-G144926

Source:

E. coli

Tag:

GST, N-terminus + His, C-terminus

Molecular Weight:

84.8 kDa

Price:

50 µg/$419

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Human ACVR1B / ALK4 Protein (Recombinant GST) (Full Length) - LS-G27352

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

81.29 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ACVR1B / ALK4 Protein (Recombinant 6His, N-terminus) (Asn150-Ile505) - LS-G26580

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

43 kDa

Price:

10 µg/$265; 20 µg/$291; 50 µg/$315

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Human ACVR1B / ALK4 Protein (Recombinant GST, N-terminus) (aa24-126) - LS-G57691

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ACVR1B / ALK4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78776

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.81 kDa

Price:

20 µg/$150

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ACVR1B / ALK4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100255

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.81 kDa

Price:

100 µg/$494

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Mouse ACVR1B / ALK4 Protein (Recombinant Fc, C-terminus) (Leu32-Glu126) - LS-G40165

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

37.7kD

Price:

10 µg/$266; 50 µg/$343; 500 µg/$1,377; 1 mg/$1,765

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Human ACVR1B / ALK4 Protein (Recombinant 6His, C-terminus) - LS-G136780

Source:

Mammalian Cells

Tag:

6His, C-terminus

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

12.46 kDa

Price:

50 µg/$313; 10 µg/$259; 1 mg/$1,470; 500 µg/$1,025

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Human ACVR1B / ALK4 Protein (Recombinant 6His, C-terminus) (Ser24-Glu126) - LS-G39322

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

12.46kD

Price:

10 µg/$248; 50 µg/$288; 500 µg/$785; 1 mg/$1,203

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Rat ACVR1B / ALK4 Protein (Recombinant Fc, C-terminus) (Met1-Glu126) - LS-G138217

Source:

HEK 293 Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

38.4 kDa

Price:

100 µg/$721

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Human ACVR1B / ALK4 Protein (Recombinant 6His, C-terminus) (Ser24-Glu126) - LS-G138612

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

12.5 kDa

Price:

10 µg/$248; 50 µg/$288

Select

Mouse ACVR1B / ALK4 Protein (Recombinant Fc, C-terminus) (Leu32-Glu126) - LS-G138844

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

37.7 kDa

Price:

10 µg/$266; 50 µg/$339

Select

Mouse ACVR1B / ALK4 Protein (Recombinant His) (aa207-385) - LS-G14767

Source:

E. coli

Tag:

His

Molecular Weight:

21.7 kDa

Price:

10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136

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