ACVR1B / ALK4

activin A receptor, type IB

Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.

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Products

Antibodies (56)

Proteins (14)

ELISA Kits (2)

Type

Cell-Based (1)

Custom (1)

Over-Expression Lysate (2)

Primary (56)

Recombinant (12)

Target

ACVR1B / ALK4 (72)

Reactivity

Human (43)

Mouse (35)

Rat (9)

Monkey (1)

Application

IHC (5)

IHC-P (3)

WB (50)

Flo (9)

ELISA (26)

IF (6)

Neut (1)

Peptide-ELISA (2)

Host

rabbit (43)

mouse (10)

goat (3)

Product Group

IHCPlus (2)

Isotype

IgG (21)

IgG1 (1)

IgG1,k (7)

IgG2a,k (1)

IgG2b (1)

Clonality

monoclonal mc (10)

polyclonal pc (46)

Clone

179CT11.2.1 (6)

2D4 (1)

Format

96-Well Microplate (2)

APC (2)

APC Conjugated (4)

Azide-free (2)

Biotin Conjugated (7)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (4)

Unconjugated (27)

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Epitope

aa207-385 (8)

aa24-126 (8)

aa134-164 (7)

Extracellular Domain (4)

50-130 aa, Internal (1)

C-Terminus (1)

Gly111 (1)

Internal (1)

aa154-415 (1)

aa39-68 (1)

aa73-122 (1)

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Publications

No (71)

Yes (1)

Sample Type

Adherent Cell Cultures (1)

Tag

6His, C-terminus (3)

6His, N-terminus (1)

Fc, C-terminus (3)

GST (1)

GST, N-terminus (1)

GST, N-terminus + His, C-terminus (1)

His (2)

Myc-DDK (Flag) (2)

Species

Human (9)

Mouse (3)

Rat (1)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (2)

Human Cells (2)

Mammalian Cells (3)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (6)

Biologically Active

Biologically active (1)

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IHC-plus™ ACVR1B / ALK4 Antibody LS-B2695

(5.0) Rating

(1) Publication(s)

Antibody:

ACVR1B / ALK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$545

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ACVR1B / ALK4 Antibody (aa73-122) LS-C118878

Antibody:

ACVR1B / ALK4 Rabbit anti-Human Polyclonal (aa73-122) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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ACVR1B / ALK4 Antibody (Extracellular Domain) LS-C124879

Antibody:

ACVR1B / ALK4 Goat anti-Human Polyclonal (Extracellular Domain) Antibody

Reactivity:

Human

Applications:

ELISA, Neut, WB

Format:

Unconjugated

Price:

100 µg/$929

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Mouse/Human/Rat ACVR1B / ALK4 (Cell-Based ELISA) ELISA Kit - LS-F3095

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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ACVR1B / ALK4 Antibody (Gly111) LS-C176756

Antibody:

ACVR1B / ALK4 Rabbit anti-Human Polyclonal (Gly111) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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Human ACVR1B / ALK4 Protein (Recombinant His) (aa24-126) - LS-G14764

Source:

E. coli

Tag:

His

Molecular Weight:

12.9 kDa

Price:

10 µg/$273; 50 µg/$390; 100 µg/$622; 200 µg/$777; 1 mg/$1,840; 500 µg/$1,398; 5 mg/$2,801; 2 mg/$2,023

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ACVR1B / ALK4 Antibody (aa39-68) LS-C97141

Antibody:

ACVR1B / ALK4 Rabbit anti-Human Polyclonal (aa39-68) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Flo, WB

Format:

Unconjugated

Price:

400 µl/$393

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ACVR1B / ALK4 Antibody (Extracellular Domain) LS-C126593

Antibody:

ACVR1B / ALK4 Mouse anti-Human Monoclonal (Extracellular Domain) Antibody

Reactivity:

Human

Applications:

ELISA, Flo

Format:

Unconjugated

Price:

100 µg/$941

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ACVR1B / ALK4 Antibody (aa134-164) LS-C97143

Antibody:

ACVR1B / ALK4 Rabbit anti-Human Polyclonal (aa134-164) Antibody

Reactivity:

Mouse, Human

Applications:

Flo, WB

Format:

Unconjugated

Price:

400 µl/$393

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ACVR1B / ALK4 Antibody (aa207-385, PE) LS-C725135

Antibody:

ACVR1B / ALK4 Rabbit anti-Mouse Polyclonal (aa207-385) (PE) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

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ACVR1B / ALK4 Antibody (50-130 aa, Internal) LS-C381906

Antibody:

ACVR1B / ALK4 Rabbit anti-Human Polyclonal (50-130 aa, Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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IHC-plus™ ACVR1B / ALK4 Antibody (Internal) LS-B13175

(4.0) Rating

Antibody:

ACVR1B / ALK4 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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ACVR1B / ALK4 Antibody (aa134-164) LS-C326784

Antibody:

ACVR1B / ALK4 Rabbit anti-Human Polyclonal (aa134-164) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, WB

Format:

Unconjugated

Price:

200 µl/$734

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ACVR1B / ALK4 Antibody (aa134-164, Biotin) LS-C274863

Antibody:

ACVR1B / ALK4 Rabbit anti-Human Polyclonal (aa134-164) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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ACVR1B / ALK4 Antibody (aa134-164, FITC) LS-C274864

Antibody:

ACVR1B / ALK4 Rabbit anti-Human Polyclonal (aa134-164) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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ACVR1B / ALK4 Antibody (aa134-164, PE) LS-C274866

Antibody:

ACVR1B / ALK4 Rabbit anti-Human Polyclonal (aa134-164) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

ACVR1B / ALK4 Antibody (aa134-164, APC) LS-C274862

Antibody:

ACVR1B / ALK4 Rabbit anti-Human Polyclonal (aa134-164) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, WB

Format:

APC Conjugated

Price:

200 µl/$952

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ACVR1B / ALK4 Antibody (aa134-164, Azide-free, HRP) LS-C274865

Antibody:

ACVR1B / ALK4 Rabbit anti-Human Polyclonal (aa134-164) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, Flo, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• PE
• APC
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • PE
  • APC
  • HRP, Azide-free

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ACVR1B / ALK4 Antibody LS-C822714

Antibody:

ACVR1B / ALK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$357

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ACVR1B / ALK4 Antibody (clone 179CT11.2.1) LS-C319100

Antibody:

ACVR1B / ALK4 Mouse anti-Mouse Monoclonal (179CT11.2.1) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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ACVR1B / ALK4 Antibody (clone 179CT11.2.1, APC) LS-C250084

Antibody:

ACVR1B / ALK4 Mouse anti-Mouse Monoclonal (APC) (179CT11.2.1) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

• Unconjugated
• APC

• Unconjugated
• APC

Select

ACVR1B / ALK4 Antibody LS-C801529

Antibody:

ACVR1B / ALK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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ACVR1B / ALK4 Antibody LS-C417314

Antibody:

ACVR1B / ALK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

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ACVR1B / ALK4 Antibody LS-C334069

Antibody:

ACVR1B / ALK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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ACVR1B / ALK4 Antibody (clone 2D4) LS-C196609

Antibody:

ACVR1B / ALK4 Mouse anti-Human Monoclonal (2D4) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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