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ACO2 / Aconitase 2

aconitase 2, mitochondrial

ACO2 / Aconitase 2 belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.

Gene Name:	aconitase 2, mitochondrial
Synonyms:	ACO2, ACONM, Aconitase 2, Aconitase 2, mitochondrial, Citrate hydro-lyase, ICRD
Target Sequences:	NM_001098 NP_001089.1 Q99798

Publications (1)

PTEN/Akt signaling controls mitochondrial respiratory capacity through 4E-BP1. Goo CK, Lim HY, Ho QS, Too HP, Clement MV, Wong KP. PloS one. 2012 7:e45806. [PubMed:23049865] [PMC:PMC3458951]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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