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ACLY / ATP Citrate Lyase

ATP citrate lyase

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Gene Name: ATP citrate lyase
Synonyms: ACLY, ACL, ATP citrate synthase, ATPCL, ATP citrate lyase, ATP-citrate (pro-S-)-lyase, CLATP, ATP-citrate synthase, Citrate cleavage enzyme, Citrate Lyase
Target Sequences: NM_001096 NP_001087.2 P53396

Publications (2)

1
Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress. King FW, Fong S, Griffin C, Shoemaker M, Staub R, Zhang YL, Cohen I, Shtivelman E. PloS one. 2009 4:e7283. (WB) [PubMed:19789631] [PMC:PMC2747272]
2
Hypoxia further exacerbates woody breast myopathy in broilers via alteration of satellite cell fate. Nima K Emami, Reagan N Cauble, Ahmed E Dhamad, Elizabeth S Greene, Cynthia S Coy, Sandra G Velleman, Sara Orlowski, Nicholas Anthony, Mike Bedford, Sami Dridi. Poultry science. 2021 Jul;;100:101167. [Full Text Article] [PubMed:34091348] [PMC:PMC8182261]

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ACLY / ATP Citrate Lyase (9)
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ACLY / ATP Citrate Lyase ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
ACLY / ATP Citrate Lyase ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
ACLY / ATP Citrate Lyase ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.56 - 100 IU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ACLY / ATP Citrate Lyase ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
ACLY / ATP Citrate Lyase ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
ACLY / ATP Citrate Lyase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ACLY / ATP Citrate Lyase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ACLY / ATP Citrate Lyase ELISA Kit
Select
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
ACLY / ATP Citrate Lyase ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1.56 - 100 U/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).