ACKR1 / DARC

Duffy blood group, atypical chemokine receptor

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.

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Products

Proteins (7)

Type

Over-Expression Lysate (4)

Recombinant (3)

Target

ACKR1 / DARC (7)

Publications

No (7)

Tag

GST (1)

His-GST (1)

Myc-DDK (Flag) (5)

Species

Human (4)

Mouse (1)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (1)

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Mouse ACKR1 / DARC Protein (Recombinant His-GST) (aa71-330) - LS-G14143

Source:

E. coli

Tag:

His-GST

Molecular Weight:

60.4 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human ACKR1 / DARC Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65478

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.4 kDa

Price:

20 µg/$1,107

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Human ACKR1 / DARC Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75645

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.5 kDa

Price:

20 µg/$150

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Human ACKR1 / DARC Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75646

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.4 kDa

Price:

20 µg/$150

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Human ACKR1 / DARC Protein (Recombinant GST) (Full Length) - LS-G28534

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

62.7 kDa

Price:

10 µg/$479; 25 µg/$670

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ACKR1 / DARC Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124451

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.5 kDa

Price:

100 µg/$494

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ACKR1 / DARC Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99628

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

35.4 kDa

Price:

100 µg/$494

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