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ACKR1 / DARC
Duffy blood group, atypical chemokine receptor
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
| Gene Name: | Duffy blood group, atypical chemokine receptor |
| Family/Subfamily: | GPCR , Chemokine |
| Synonyms: | ACKR1, CD234, CD234 antigen, DARC, Duffy antigen, Duffy blood group, Duffy group antigen, Dfy, FY, Fy glycoprotein, Plasmodium vivax receptor, WBCQ1, CCBP1, Duffy blood group antigen, Glycoprotein D, GPD, GpFy |
| Target Sequences: | NM_002036 NP_002027.2 Q16570 |
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