ACIN1 / Acinus

apoptotic chromatin condensation inducer 1

Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.

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Proteins (5)

Type

Over-Expression Lysate (4)

Recombinant (1)

Target

ACIN1 / Acinus (5)

Publications

No (5)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (4)

Species

Human (3)

Source

293T Cells (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human ACIN1 / Acinus Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G61895

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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Human ACIN1 / Acinus Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90094

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

70.8 kDa

Price:

20 µg/$150

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Human ACIN1 / Acinus Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90095

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.4 kDa

Price:

20 µg/$150

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ACIN1 / Acinus Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128279

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

70.8 kDa

Price:

100 µg/$494

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ACIN1 / Acinus Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128251

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.4 kDa

Price:

100 µg/$494

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