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Acetyl-CoA Carboxylase / ACC

acetyl-CoA carboxylase alpha

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.

Gene Name: acetyl-CoA carboxylase alpha
Synonyms: ACACA, ACAC, ACC1, ACACAD, ACCA, ACC, ACC-alpha, Acetyl-CoA Carboxylase, Acetyl-CoA carboxylase 1, Acetyl-CoA carboxylase alpha
Target Sequences: Q13085 Q13085

Publications (2)

1
Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin. Wong GW, Krawczyk SA, Kitidis-Mitrokostas C, Ge G, Spooner E, Hug C, Gimeno R, Lodish HF. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2009 23:241-58. (WB) [PubMed:18787108] [PMC:PMC2626616]
2
Effects of atypical antipsychotics and haloperidol on PC12 cells: only aripiprazole phosphorylates AMP-activated protein kinase. Takami G, Ota M, Nakashima A, Kaneko YS, Mori K, Nagatsu T, Ota A. Journal of neural transmission (Vienna, Austria : 1996). 2010 117:1139-53. (WB; Rat) [PubMed:20686905] Related Antibodies: LS-C11718.

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Proteins (9)
Over-Expression Lysate (2)
Recombinant (7)
Acetyl-CoA Carboxylase / ACC (9)
No (9)
10His, N-terminus (4)
6His, N-terminus (2)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Candida albicans (1)
Candida glabrata (1)
Human (2)
Rat (2)
Saccharomyces cerevisiae (2)
293T Cells (1)
E. coli (5)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Yeast (1)
Purified (6)
Acetyl-CoA Carboxylase / ACC Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
10His, N-terminus
69.9 kDa
20 µg/$405; 1 mg/$1,679; 100 µg/$598
Acetyl-CoA Carboxylase / ACC Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
259.5 kDa
100 µg/$710
Acetyl-CoA Carboxylase / ACC Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
259.5 kDa
20 µg/$215
Acetyl-CoA Carboxylase / ACC Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
10His, N-terminus
67.6 kDa
20 µg/$405; 1 mg/$1,679; 100 µg/$598
Acetyl-CoA Carboxylase / ACC Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
10His, N-terminus
67.2 kDa
20 µg/$405; 1 mg/$1,679; 100 µg/$598
Acetyl-CoA Carboxylase / ACC Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
10His, N-terminus
67.3 kDa
1 mg/$1,679; 100 µg/$598; 20 µg/$405
Acetyl-CoA Carboxylase / ACC Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Acetyl-CoA Carboxylase / ACC Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, N-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
Acetyl-CoA Carboxylase / ACC Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Yeast
6His, N-terminus
100 µg/$570; 20 µg/$395; 1 mg/$1,973
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).