ACER2

alkaline ceramidase 2

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)-ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)-ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate.

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Antibodies (10)

Type

Primary (10)

Target

ACER2 (10)

Reactivity

Human (10)

Mouse (8)

Rat (5)

Bat (3)

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Chimpanzee (3)

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Guinea pig (3)

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Application

IHC (1)

WB (10)

ELISA (2)

IF (1)

Peptide-ELISA (1)

Host

rabbit (10)

Isotype

IgG (2)

Clonality

polyclonal pc (10)

Format

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

Unconjugated (7)

Epitope

aa93-142 (4)

Internal (1)

Publications

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Yes (1)

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ACER2 Antibody (Internal) LS-C354506

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(1) Publication(s)

Antibody:

ACER2 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$299

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ACER2 Antibody (aa93-142) LS-C152143

Antibody:

ACER2 Rabbit anti-Human Polyclonal (aa93-142) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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ACER2 Antibody (aa93-142, HRP) LS-C473793

Antibody:

ACER2 Rabbit anti-Human Polyclonal (aa93-142) (HRP) Antibody

Reactivity:

Rabbit, Mouse, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

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ACER2 Antibody (aa93-142, Biotin) LS-C473791

Antibody:

ACER2 Rabbit anti-Human Polyclonal (aa93-142) (Biotin) Antibody

Reactivity:

Rabbit, Mouse, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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ACER2 Antibody (aa93-142, FITC) LS-C473792

Antibody:

ACER2 Rabbit anti-Human Polyclonal (aa93-142) (FITC) Antibody

Reactivity:

Rabbit, Mouse, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
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  • FITC

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ACER2 Antibody LS-C813327

Antibody:

ACER2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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ACER2 Antibody LS-C804784

Antibody:

ACER2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human, Monkey

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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ACER2 Antibody LS-C415683

Antibody:

ACER2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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ACER2 Antibody LS-C659032

Antibody:

ACER2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$386

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ACER2 Antibody LS-C411963

Antibody:

ACER2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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