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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
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ACE2 / ACE-2
angiotensin I converting enzyme 2
Angiotensin-Converting Enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function. ACE2 is also the attachment receptor for HCoV-N63, SARS-CoV and SARS-CoV-2. The S1 portion of the coronavirus spike protein attaches to ACE2 presented on the host cell surface. The SARS-CoV-2 virus targets pneumocytes and macrophages expressing ACE2 in the lung, and it is believed to infect ACE2-positive cells in other tissues including the gastrointestinal tract and potentially the liver (in cholangiocytes).
Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms. Adedeji AO, Severson W, Jonsson C, Singh K, Weiss SR, Sarafianos SG. Journal of virology. 2013 87:8017-28. (IHC; Human)[Full Text Article]
[PubMed:23678171]
[PMC:PMC3700180]
Related Antibodies: LS-C122669.
2
Short-term exposure to dexamethasone promotes autonomic imbalance to the heart before hypertension. Francine Duchatsch, Paula B Constantino, Naiara A Herrera, Mayara F Fabrício, Lidieli P Tardelli, Aline M Martuscelli, Thiago J Dionísio, Carlos F Santos, Sandra L Amaral. Journal of the American Society of Hypertension : JASH. 2018 August;12:605-613. [Full Text Article]
[PubMed:29945776]
3
Reduced severe acute respiratory syndrome coronavirus 2 entry factors and enhanced innate immune gene expression in the nasal epithelium of pregnant rats. Arvind Palanisamy, Tusar Giri. American journal of obstetrics and gynecology. 2020 October; [Full Text Article]
[PubMed:33039392]
[PMC:PMC7544630]
Related Antibodies: LS-C763699.
4
Pregnancy as a "golden opportunity" for patient activation and engagement. Lynn M Yee, Melissa A Simon, William A Grobman, Priya V Rajan. American journal of obstetrics and gynecology. 2020 September; [Full Text Article]
[PubMed:32979375]
Related Antibodies: LS-C763699.
5
Angiotensin peptide synthesis and cyclic nucleotide modulation in sympathetic stellate ganglia. Emma N Bardsley, Oliver C Neely, David J Paterson. Journal of molecular and cellular cardiology. 2020 Jan;138:234-243. [Full Text Article]
[PubMed:31836539]
[PMC:PMC7049903]
Case series - COVID-19 is unlikely to affect male fertility: Results of histopathological and reverse transcriptase polymerase chain reaction analysis. John M Masterson, Chau Bui, Wohaib Hasan, Yi Zhang, Carissa Huynh, Harneet Jawanda, Daniel Luthringer, Warren Tourtellotte, Eric Vail, Maurice M Garcia. Canadian Urological Association journal. 2022 June; [Full Text Article]
[PubMed:35704934]
Related Antibodies: LS-B6672.
8
Exercise attenuates dexamethasone-induced hypertension through an improvement of baroreflex activity independently of the renin-angiotensin system. Paula B Constantino, Thiago J Dionísio, Francine Duchatsch, Naiara A Herrera, Josiane O Duarte, Carlos F Santos, Carlos C Crestani, Sandra L Amaral. Steroids. 2017 December;128:147-154. [Full Text Article]
[PubMed:29054562]
Related Antibodies: LS-C413153.
9
Defining the Innate Immune Responses for SARS-CoV-2-Human Macrophage Interactions. Mai M Abdelmoaty, Pravin Yeapuri, Jatin Machhi, Katherine E Olson, Farah Shahjin, Vikas Kumar, You Zhou, Jingjing Liang, Kabita Pandey, Arpan Acharya, Siddappa N Byrareddy, R Lee Mosley, Howard E Gendelman. Frontiers in immunology. 2021 October;12:741502. [Full Text Article]
[PubMed:34671355]
[PMC:PMC8521106]
Related Antibodies: LS-C275129.
10
Pancreatic angiotensin-converting enzyme 2 improves glycemia in angiotensin II-infused mice. Chhabra KH, Xia H, Pedersen KB, Speth RC, Lazartigues E. American journal of physiology. Endocrinology and metabolism. 2013 Apr;304:E874-84. [Full Text Article]
[PubMed:23462816]
[PMC:PMC3625779]
Related Antibodies: LS-B3197.
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PLEASE NOTE
For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).