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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ACE2 / ACE-2

angiotensin I converting enzyme 2

Angiotensin-Converting Enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function. ACE2 is also the attachment receptor for HCoV-N63, SARS-CoV and SARS-CoV-2. The S1 portion of the coronavirus spike protein attaches to ACE2 presented on the host cell surface. The SARS-CoV-2 virus targets pneumocytes and macrophages expressing ACE2 in the lung, and it is believed to infect ACE2-positive cells in other tissues including the gastrointestinal tract and potentially the liver (in cholangiocytes).

Gene Name: angiotensin I converting enzyme 2
Family/Subfamily: Protease , Metallopeptidase M2
Synonyms: ACE2, ACE-related carboxypeptidase, ACEH, Metalloprotease MPROT15, SARS-CoV2 Coronavirus Receptor, SARS-CoV-2 Coronavirus Receptor, COVID-19 viral receptor
Target Sequences: NM_021804 NP_068576.1 Q9BYF1

Publications (2)

1
Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms. Adedeji AO, Severson W, Jonsson C, Singh K, Weiss SR, Sarafianos SG. Journal of virology. 2013 87:8017-28. (IHC; Human) [Full Text Article] [PubMed:23678171] [PMC:PMC3700180] Related Antibodies: LS-C122669.
2
Pancreatic angiotensin-converting enzyme 2 improves glycemia in angiotensin II-infused mice. Chhabra KH, Xia H, Pedersen KB, Speth RC, Lazartigues E. American journal of physiology. Endocrinology and metabolism. 2013 Apr;304:E874-84. [Full Text Article] [PubMed:23462816] [PMC:PMC3625779] Related Antibodies: LS-B3197.

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Products
ELISA Kits (28)
Competitive EIA (2)
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ACE2 / ACE-2 (28)
Human (10)
Mouse (6)
Rat (6)
Chicken (1)
Guinea pig (1)
Monkey (1)
Porcine (1)
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Coronavirus Detection (28)
ELISA Kits for Associated Targets (28)
12 x 8-Well Microstrips (1)
96-Well Microplate (4)
96-Well Strip Plate (23)
No (28)
Cell Culture Supernatants (7)
Cell Lysates (1)
Plasma (22)
Serum (22)
Tissue Homogenates (7)
ACE2 / ACE-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$510
ACE2 / ACE-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
12.5 - 800 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$780
ACE2 / ACE-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$700
ACE2 / ACE-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$620
ACE2 / ACE-2 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.391 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$590
ACE2 / ACE-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$810
ACE2 / ACE-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$700
ACE2 / ACE-2 ELISA Kit
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Sandwich
96-Well Microplate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$560
ACE2 / ACE-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$660
ACE2 / ACE-2 ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$700
ACE2 / ACE-2 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$700
ACE2 / ACE-2 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$560
ACE2 / ACE-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$620
ACE2 / ACE-2 ELISA Kit
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Sandwich
96-Well Microplate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$590
ACE2 / ACE-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$870
ACE2 / ACE-2 ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$870
ACE2 / ACE-2 ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
250 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$870
ACE2 / ACE-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
1.56 - 100 IU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$870
ACE2 / ACE-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
6.25 - 400 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$870
ACE2 / ACE-2 ELISA Kit
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Custom
96-Well Strip Plate
Chicken
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$660
ACE2 / ACE-2 ELISA Kit
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Custom
96-Well Strip Plate
Porcine
0.391 - 25 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$660
ACE2 / ACE-2 ELISA Kit
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Custom
96-Well Strip Plate
Guinea pig
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$660
ACE2 / ACE-2 ELISA Kit
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Custom
96-Well Strip Plate
Rabbit
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$660
ACE2 / ACE-2 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$870
ACE2 / ACE-2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.391 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$790
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).