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ACD / PTOP

adrenocortical dysplasia homolog (mouse)

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis.

Gene Name:	adrenocortical dysplasia homolog (mouse)
Synonyms:	ACD, PTOP, TIN2 interacting protein 1, TINT1, PIP1
Target Sequences:	NM_022914 NP_075065.2 Q96AP0

Publications (1)

Transcriptome analyses of ovarian stroma: tunica albuginea, interstitium and theca interna. Katja Hummitzsch, Nicholas Hatzirodos, Anne M Macpherson, Jeff Schwartz, Raymond J Rodgers, Helen F Irving-Rodgers. Reproduction (Cambridge, England). 2019 Jun;;157:545-565. [Full Text Article] [PubMed:30925461] Related Antibodies: LS-C108067.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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