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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ACAN / Aggrecan

aggrecan

This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.

Gene Name: aggrecan
Synonyms: ACAN, AGCAN, Aggrecan core protein, Acg1, Aggrecan, CSPG1, CSPGCP, CSPCP, AGC1, Aggrecan 1, Large aggregating proteoglycan, MSK16, SEDK, MCSPG
Target Sequences: NM_013227 NP_037359.3 P16112

Publications (3)

1
Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation. Little CB, Hughes CE, Curtis CL, Janusz MJ, Bohne R, Wang-Weigand S, Taiwo YO, Mitchell PG, Otterness IG, Flannery CR, Caterson B. Matrix biology : journal of the International Society for Matrix Biology. 2002 21:271-88. [PubMed:12009333]
2
A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs. Swearingen CA, Chambers MG, Lin C, Marimuthu J, Rito CJ, Carter QL, Dotzlaf J, Liu C, Chandrasekhar S, Duffin KL, Mitchell PG, Durham TB, Wiley MR, Thirunavukkarasu K. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2010 18:1159-66. (WB; Bovine, Human, Rat) [PubMed:20633676]
3
Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration. Yurube T, Takada T, Suzuki T, Kakutani K, Maeno K, Doita M, Kurosaka M, Nishida K. Arthritis research & therapy. 2012 14:R51. (IHC; Rat) [PubMed:22394620] [PMC:PMC3446417]

Filtered by: None
Target
ACAN / Aggrecan (116)
Reactivity
Human (76)
Mouse (32)
Rat (42)
Bat (1)
Bovine (15)
Cow (8)
Dog (7)
Hamster (14)
Monkey (16)
Pig (14)
Rabbit (2)
Sheep (1)
Application
IHC (45)
IHC-Fr (8)
IHC-P (36)
WB (86)
Flo (5)
ELISA (17)
ICC (5)
IF (7)
IP (4)
Peptide-ELISA (1)
Host
rabbit (101)
mouse (14)
goat (1)
Isotype
IgG (7)
IgG1 (10)
IgG1,k (2)
IgG2b (1)
IgG3 (1)
Clonality
monoclonal mc (14)
polyclonal pc (102)
Clone
2A8 (1)
6-B-4 (1)
7D4 (1)
7E1 (1)
TS106 (1)
Format
AP Conjugated (5)
APC (7)
APC Conjugated (12)
Azide-free (4)
Biotin Conjugated (13)
Cy3 Conjugated (7)
Cy7 Conjugated (7)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (12)
HRP Conjugated (12)
PE Conjugated (12)
Unconjugated (33)
Epitope
aa34-147 (22)
C-Terminus (14)
N-Terminus (9)
aa2066-2316 (8)
aa2162-2316 (8)
aa587-684 (8)
aa588-684 (8)
Internal (6)
aa2163-2316 (3)
aa20-675 (2)
290-370 aa, N-terminal (1)
Cleaved (1)
aa200-250 (1)
aa320-369 (1)
aa350-400 (1)
aa361-369 (1)
aa384-392 (1)
Publications
No (116)
Showing 1-25 of 116 results

IHC-plus™ ACAN / Aggrecan Antibody (C-Terminus) LS-A1561
Rabbit Polyclonal to Human ACAN / Aggrecan
Human
IHC, IHC-P
Unconjugated
50µg 1mg/ml  $425.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)

IHC-plus™ ACAN / Aggrecan Antibody (C-Terminus, Biotin) LS-A101467
Rabbit Polyclonal to Human ACAN / Aggrecan
Human
IHC, IHC-P
Biotin Conjugated
100µl  $650.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)

IHC-plus™ ACAN / Aggrecan Antibody (C-Terminus, FITC) LS-A101468
Rabbit Polyclonal to Human ACAN / Aggrecan
Human
IHC, IHC-P
FITC Conjugated
100µl  $650.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)

IHC-plus™ ACAN / Aggrecan Antibody (C-Terminus, PE) LS-A101470
Rabbit Polyclonal to Human ACAN / Aggrecan
Human
IHC, IHC-P
PE Conjugated
100µl 0.95mg/ml  $650.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)

IHC-plus™ ACAN / Aggrecan Antibody (C-Terminus, AP) LS-A101465
Rabbit Polyclonal to Human ACAN / Aggrecan
Human
IHC, IHC-P
AP Conjugated
100µl  $650.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)

IHC-plus™ ACAN / Aggrecan Antibody (C-Terminus, APC) LS-A101466
Rabbit Polyclonal to Human ACAN / Aggrecan
Human
IHC, IHC-P
APC Conjugated
100µl  $650.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)

IHC-plus™ ACAN / Aggrecan Antibody (C-Terminus, Azide-free, HRP) LS-A101469
Rabbit Polyclonal to Human ACAN / Aggrecan
Human
IHC, IHC-P
HRP Conjugated, Azide-free
100µl  $650.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)

IHC-plus™ ACAN / Aggrecan Antibody (N-Terminus) LS-A1556
Rabbit Polyclonal to Human ACAN / Aggrecan
Hamster, Pig, Human, Monkey
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-ACAN / Aggrecan antibody IHC of human bone, cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

ACAN / Aggrecan Antibody (aa350-400) LS-C359243
Rabbit Polyclonal to Human ACAN / Aggrecan
Mouse, Dog, Bovine, Rat, Pig, Human
Flo, ICC, IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100µl 1mg/ml  $335.00
Immunohistochemistry: Aggrecan Neoepitope Antibody - Analysis of ACAN in mouse cartilage with hematoxylin counterstain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Immunocytochemistry/Immunofluorescence: Aggrecan Neoepitope Antibody - Detection of ACAN in OA cartilage using ACAN antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

ACAN / Aggrecan Antibody (Biotin) LS-C181057
Rabbit Polyclonal to Human ACAN / Aggrecan
Mouse, Dog, Bovine, Rat, Pig, Human
Flo, ICC, IF, IHC, IHC-Fr, IHC-P, WB
Biotin Conjugated
100µl 1mg/ml  $365.00
Immunohistochemistry: Aggrecan Neoepitope Antibody - Analysis of ACAN in mouse cartilage with hematoxylin counterstain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Immunocytochemistry/Immunofluorescence: Aggrecan Neoepitope Antibody - Detection of ACAN in OA cartilage using ACAN antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

ACAN / Aggrecan Antibody (DY650) LS-C181058
Rabbit Polyclonal to Human ACAN / Aggrecan
Mouse, Dog, Bovine, Rat, Pig, Human
Flo, ICC, IF, IHC, IHC-Fr, IHC-P, WB
DY650 Conjugated
100µl 1mg/ml  $365.00
Immunohistochemistry: Aggrecan Neoepitope Antibody - Analysis of ACAN in mouse cartilage with hematoxylin counterstain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Immunocytochemistry/Immunofluorescence: Aggrecan Neoepitope Antibody - Detection of ACAN in OA cartilage using ACAN antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

ACAN / Aggrecan Antibody (DY488) LS-C181059
Rabbit Polyclonal to Human ACAN / Aggrecan
Mouse, Dog, Bovine, Rat, Pig, Human
Flo, ICC, IF, IHC, IHC-Fr, IHC-P, WB
DY488 Conjugated
100µl 1mg/ml  $365.00
Immunohistochemistry: Aggrecan Neoepitope Antibody - Analysis of ACAN in mouse cartilage with hematoxylin counterstain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Immunocytochemistry/Immunofluorescence: Aggrecan Neoepitope Antibody - Detection of ACAN in OA cartilage using ACAN antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

ACAN / Aggrecan Antibody (DY550) LS-C181061
Rabbit Polyclonal to Human ACAN / Aggrecan
Mouse, Dog, Bovine, Rat, Pig, Human
Flo, ICC, IF, IHC, IHC-Fr, IHC-P, WB
DY550 Conjugated
100µl 1mg/ml  $365.00
Immunohistochemistry: Aggrecan Neoepitope Antibody - Analysis of ACAN in mouse cartilage with hematoxylin counterstain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Immunocytochemistry/Immunofluorescence: Aggrecan Neoepitope Antibody - Detection of ACAN in OA cartilage using ACAN antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

ACAN / Aggrecan Antibody (N-Terminus) LS-C351811
Rabbit Polyclonal to Human ACAN / Aggrecan
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $245.00
Immunohistochemical analysis of Aggrecan staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Western blot analysis of Aggrecan expression in HeLa colchicine-treated (A); mouse kidney (B); PC12 colchicine-treated (C); NIH3T3 (D) whole cell lysates.

IHC-plus™ ACAN / Aggrecan Antibody (C-Terminus) LS-A1562
Rabbit Polyclonal to Human ACAN / Aggrecan
Rat, Hamster, Human, Monkey
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-ACAN / Aggrecan antibody IHC of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

ACAN / Aggrecan Antibody (clone 6-B-4) LS-C179972
Mouse Monoclonal [clone 6-B-4] (IgG1,k) to Human ACAN / Aggrecan
Human, Monkey
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
1000µl 1mg/ml  $365.00

ACAN / Aggrecan Antibody (clone 7D4) LS-C187469
Mouse Monoclonal [clone 7D4] (IgG1) to Human ACAN / Aggrecan
Human
ELISA, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
0.2mg  $475.00
Recombinant human aggrecan detected with Mouse anti-Human Aggrecan followed by Goat anti-Mouse IgG:Dylight800. Visualized using a LI-COR Odyssey infrared imaging system

ACAN / Aggrecan Antibody (aa361-369) LS-C20344
Mouse Monoclonal (IgG1) to Human ACAN / Aggrecan
Rabbit, Dog, Bovine, Rat, Pig, Bat, Human, Monkey
ELISA, WB
Unconjugated
100µg  $680.00

ACAN / Aggrecan Antibody (aa34-147) LS-C292677
Rabbit Polyclonal to Human ACAN / Aggrecan
Human
WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $295.00; 1ml 0.5mg/ml  $495.00
Western blot Image
Western blot Image

ACAN / Aggrecan Antibody (clone 7E1) LS-C745632
Mouse Monoclonal [clone 7E1] (IgG1) to Human ACAN / Aggrecan
Human
ELISA, IHC, IHC-Fr, IP, WB
Unconjugated
0.2mg  $395.00

ACAN / Aggrecan Antibody (aa20-675) LS-C122622
Mouse Monoclonal (IgG2b) to Human ACAN / Aggrecan
Human
ELISA, IHC, IP, WB
Unconjugated
500µg  $815.00

ACAN / Aggrecan Antibody LS-C20352
Mouse Monoclonal (IgG1) to Human ACAN / Aggrecan
Human
ELISA, IHC, WB
Unconjugated
500µg  $605.00

ACAN / Aggrecan Antibody (clone 2A8) LS-C196626
Mouse Monoclonal [clone 2A8] (IgG1,k) to Human ACAN / Aggrecan
Human
ELISA, IF, WB
Unconjugated
100µg  $365.00
Immunofluorescence of monoclonal antibody to ACAN on HeLa cell . [antibody concentration 10 ug/ml]
Detection limit for recombinant GST tagged AGC1 is approximately 0.1 ng/ml as a capture antibody.

ACAN / Aggrecan Antibody (290-370 aa, N-terminal) LS-C380496
Rabbit Polyclonal (IgG) to Human ACAN / Aggrecan
Rat, Human
ELISA, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00

ACAN / Aggrecan Antibody LS-C659413
Rabbit Polyclonal (IgG) to Human ACAN / Aggrecan
Human
ELISA, IHC, WB
Unconjugated
100µg  $405.00
Showing 1-25 of 116 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).