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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ACAN / Aggrecan

aggrecan

This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.

Gene Name: aggrecan
Synonyms: ACAN, AGCAN, Aggrecan core protein, Acg1, Aggrecan, CSPG1, CSPGCP, CSPCP, AGC1, Aggrecan 1, Large aggregating proteoglycan, MSK16, SEDK, MCSPG
Target Sequences: NM_013227 NP_037359.3 P16112

Publications (3)

1
Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation. Little CB, Hughes CE, Curtis CL, Janusz MJ, Bohne R, Wang-Weigand S, Taiwo YO, Mitchell PG, Otterness IG, Flannery CR, Caterson B. Matrix biology : journal of the International Society for Matrix Biology. 2002 21:271-88. [PubMed:12009333]
2
A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs. Swearingen CA, Chambers MG, Lin C, Marimuthu J, Rito CJ, Carter QL, Dotzlaf J, Liu C, Chandrasekhar S, Duffin KL, Mitchell PG, Durham TB, Wiley MR, Thirunavukkarasu K. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2010 18:1159-66. (WB; Bovine, Human, Rat) [PubMed:20633676]
3
Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration. Yurube T, Takada T, Suzuki T, Kakutani K, Maeno K, Doita M, Kurosaka M, Nishida K. Arthritis research & therapy. 2012 14:R51. (IHC; Rat) [PubMed:22394620] [PMC:PMC3446417]


ACAN / Aggrecan Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal to Human ACAN / Aggrecan
Human
IHC, IHC-P
Unconjugated
50µg   1mg/ml   $425.00
ACAN / Aggrecan Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal to Human ACAN / Aggrecan
Human
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
ACAN / Aggrecan Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal to Human ACAN / Aggrecan
Human
IHC, IHC-P
FITC Conjugated
100µl   $650.00
ACAN / Aggrecan Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal to Human ACAN / Aggrecan
Human
IHC, IHC-P
PE Conjugated
100µl   0.95mg/ml   $650.00
ACAN / Aggrecan Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal to Human ACAN / Aggrecan
Human
IHC, IHC-P
AP Conjugated
100µl   $650.00
ACAN / Aggrecan Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal to Human ACAN / Aggrecan
Human
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
ACAN / Aggrecan Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal to Human ACAN / Aggrecan
Human
IHC, IHC-P
APC Conjugated
100µl   $650.00
ACAN / Aggrecan Antibody - Anti-ACAN / Aggrecan antibody IHC of human bone, cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human ACAN / Aggrecan
Hamster, Pig, Human, Monkey
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
ACAN / Aggrecan Antibody - Anti-ACAN / Aggrecan antibody IHC of human bone, cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human ACAN / Aggrecan
Hamster, Pig, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
ACAN / Aggrecan Antibody - Anti-ACAN / Aggrecan antibody IHC of human bone, cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human ACAN / Aggrecan
Hamster, Pig, Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl   $650.00
ACAN / Aggrecan Antibody - Anti-ACAN / Aggrecan antibody IHC of human bone, cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human ACAN / Aggrecan
Hamster, Pig, Human, Monkey
IHC, IHC-P
AP Conjugated
100µl   $650.00
ACAN / Aggrecan Antibody - Anti-ACAN / Aggrecan antibody IHC of human bone, cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human ACAN / Aggrecan
Hamster, Pig, Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
ACAN / Aggrecan Antibody - Anti-ACAN / Aggrecan antibody IHC of human bone, cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human ACAN / Aggrecan
Hamster, Pig, Human, Monkey
IHC, IHC-P
PE Conjugated
100µl   $650.00
ACAN / Aggrecan Antibody - Anti-ACAN / Aggrecan antibody IHC of human bone, cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human ACAN / Aggrecan
Hamster, Pig, Human, Monkey
IHC, IHC-P
APC Conjugated
100µl   $650.00
ACAN / Aggrecan Antibody - Anti-ACAN / Aggrecan antibody IHC of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human ACAN / Aggrecan
Rat, Hamster, Human, Monkey
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
ACAN / Aggrecan Antibody - Anti-ACAN / Aggrecan antibody IHC of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human ACAN / Aggrecan
Rat, Hamster, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
ACAN / Aggrecan Antibody - Anti-ACAN / Aggrecan antibody IHC of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ACAN / Aggrecan
Rat, Hamster, Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl   $650.00
ACAN / Aggrecan Antibody - Anti-ACAN / Aggrecan antibody IHC of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ACAN / Aggrecan
Rat, Hamster, Human, Monkey
IHC, IHC-P
APC Conjugated
100µl   $650.00
ACAN / Aggrecan Antibody - Anti-ACAN / Aggrecan antibody IHC of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ACAN / Aggrecan
Rat, Hamster, Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
ACAN / Aggrecan Antibody - Anti-ACAN / Aggrecan antibody IHC of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ACAN / Aggrecan
Rat, Hamster, Human, Monkey
IHC, IHC-P
AP Conjugated
100µl   $650.00
ACAN / Aggrecan Antibody - Anti-ACAN / Aggrecan antibody IHC of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ACAN / Aggrecan
Rat, Hamster, Human, Monkey
IHC, IHC-P
PE Conjugated
100µl   $650.00
ACAN / Aggrecan Antibody - Immunohistochemistry: Aggrecan Neoepitope Antibody - Analysis of ACAN in mouse cartilage with hematoxylin counterstain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human ACAN / Aggrecan
Mouse, Dog, Bovine, Rat, Pig, Human
Flo, ICC, IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100µl   1mg/ml   $335.00
ACAN / Aggrecan Antibody - Immunohistochemistry: Aggrecan Neoepitope Antibody - Analysis of ACAN in mouse cartilage with hematoxylin counterstain.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human ACAN / Aggrecan
Mouse, Dog, Bovine, Rat, Pig, Human
Flo, ICC, IF, IHC, IHC-Fr, IHC-P, WB
DY650 Conjugated
100µl   0.56mg/ml   $365.00
ACAN / Aggrecan Antibody - Immunohistochemical analysis of Aggrecan staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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Rabbit Polyclonal to Human ACAN / Aggrecan
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $245.00
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Mouse Monoclonal [clone 6-B-4] (IgG1,k) to Human ACAN / Aggrecan
Human, Monkey
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
1000µl   1mg/ml   $365.00
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).