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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ABL2

c-abl oncogene 2, non-receptor tyrosine kinase

Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.

Gene Name: c-abl oncogene 2, non-receptor tyrosine kinase
Family/Subfamily: Protein Kinase , Abl
Synonyms: ABL2, Abl-related gene ARG, ABLL, Abelson-related gene protein, ARG, Oncogene abl2, Tyrosine-protein kinase ARG
Target Sequences: NM_007314 NP_009298.1 P42684

Filtered by: None
Type
Over-Expression Lysate (12)
Recombinant (4)
Target
ABL2 (16)
Tag
GST,N-terminus (1)
Myc + DDK (14)
Species
Human (7)
Source
293T Cells (3)
HEK 293 Cells (11)
Insect Cells (1)
Wheat Germ Extract (1)
Biologically Active
Biologically active (1)
Publications
No (16)
Showing 1-16 of 16 results

Human ABL2 Protein (Recombinant GST,N-terminus) (aa743-842) - LS-G57669
Wheat Germ Extract
GST,N-terminus
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE Stained with Coomassie Blue.

Human ABL2 Protein (Recombinant) - LS-G131586
Insect Cells
None
Biologically active
~132 kDa
10µg  $365.00

Human ABL2 Protein (Recombinant Myc + DDK) (Full Length) - LS-G67231
HEK 293 Cells
Myc + DDK
126.5 kDa
20µg  $950.00
Purified recombinant protein ABL2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining

Human ABL2 Protein (Recombinant Myc + DDK) (Full Length) - LS-G67232
HEK 293 Cells
Myc + DDK
126.5 kDa
20µg  $950.00
Purified recombinant protein ABL2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining

ABL2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G118865
HEK 293 Cells
Myc + DDK
126.5 kDa
100µg  $485.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

ABL2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G116141
HEK 293 Cells
Myc + DDK
126.5 kDa
100µg  $485.00

ABL2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G125592
HEK 293 Cells
Myc + DDK
116.7 kDa
100µg  $475.00

ABL2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G125593
HEK 293 Cells
Myc + DDK
60.7 kDa
100µg  $345.00

ABL2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G130361
HEK 293 Cells
Myc + DDK
114.6 kDa
100µg  $475.00

ABL2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G130364
HEK 293 Cells
Myc + DDK
116.3 kDa
100µg  $475.00

ABL2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G130377
HEK 293 Cells
Myc + DDK
118.4 kDa
100µg  $475.00

ABL2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G130398
HEK 293 Cells
Myc + DDK
126.7 kDa
100µg  $475.00

Human ABL2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G79390
293T Cells
Myc + DDK
126.5 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human ABL2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G79388
293T Cells
Myc + DDK
126.5 kDa
20µg  $195.00

Human ABL2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G79389
293T Cells
Myc + DDK
128.2 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

ABL2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G101013
HEK 293 Cells
Myc + DDK
128.2 kDa
100µg  $485.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Showing 1-16 of 16 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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