ABL2

c-abl oncogene 2, non-receptor tyrosine kinase

Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.

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Proteins (9)

Type

Over-Expression Lysate (6)

Recombinant (3)

Target

ABL2 (9)

Publications

No (9)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (8)

Species

Human (6)

Source

293T Cells (3)

HEK 293 Cells (5)

Wheat Germ Extract (1)

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ABL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116141

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

126.5 kDa

Price:

100 µg/$710

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ABL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118865

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

126.5 kDa

Price:

100 µg/$710

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Human ABL2 Protein (Recombinant GST, N-terminus) (aa743-842) - LS-G57669

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ABL2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67231

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

126.5 kDa

Price:

20 µg/$1,107

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Human ABL2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67232

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

126.5 kDa

Price:

20 µg/$1,107

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Human ABL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79388

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

126.5 kDa

Price:

20 µg/$215

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Human ABL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79389

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

128.2 kDa

Price:

20 µg/$215

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Human ABL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79390

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

126.5 kDa

Price:

20 µg/$215

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ABL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101013

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

128.2 kDa

Price:

100 µg/$710

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