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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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ABL2

c-abl oncogene 2, non-receptor tyrosine kinase

Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.

Gene Name: c-abl oncogene 2, non-receptor tyrosine kinase
Family/Subfamily: Protein Kinase , Abl
Synonyms: ABL2, Abl-related gene ARG, ABLL, Abelson-related gene protein, ARG, Oncogene abl2, Tyrosine-protein kinase ARG
Target Sequences: NM_007314 NP_009298.1 P42684

Viewing 1-8 of 8 items
ABL2 ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1plate   $590.00
ABL2 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
0.156 - 10 ng/ml
Chemiluminescent
Plasma, Serum
1plate   $700.00
ABL2 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Rat
0.156 - 10 ng/ml
Chemiluminescent
Plasma, Serum
1plate   $700.00
ABL2 ELISA Kit
Select
Custom
96-Well Strip Plate
Porcine
7.813 - 500 ng/ml
Colorimetric - 450nm (TMB)
1plate   $660.00
ABL2 ELISA Kit
Select
Custom
96-Well Strip Plate
Guinea pig
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1plate   $660.00
ABL2 ELISA Kit
Select
Custom
96-Well Strip Plate
Rabbit
7.813 - 500 ng/ml
Colorimetric - 450nm (TMB)
1plate   $660.00
ABL2 ELISA Kit
Select
Custom
96-Well Strip Plate
Monkey
7.813 - 500 ng/ml
Colorimetric - 450nm (TMB)
1plate   $660.00
ABL2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
25 - 1600 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1plate   $870.00

Viewing 1-8 of 8 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).