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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ABL1 / c-ABL

c-abl oncogene 1, non-receptor tyrosine kinase

Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.

Gene Name: c-abl oncogene 1, non-receptor tyrosine kinase
Family/Subfamily: Protein Kinase , Abl
Synonyms: ABL1, Bcr/c-abl oncogene protein, Bcr-Abl, Bcr/abl, C-ABL, ABL, JTK7, p150, Tyrosine-protein kinase ABL1, Proto-oncogene c-Abl, V-abl
Target Sequences: NM_005157 NP_005148.2 P00519

Filtered by: None
Target
ABL1 / c-ABL (152)
Reactivity
Human (142)
Mouse (81)
Rat (44)
Bovine (1)
Chicken (1)
Dog (1)
Horse (1)
Monkey (13)
Zebrafish (3)
Application
IHC (88)
IHC-P (20)
WB (129)
Flo (1)
DB (16)
ELISA (72)
ICC (7)
IF (32)
IP (22)
Peptide-ELISA (11)
Host
rabbit (139)
mouse (13)
Isotype
IgG (110)
IgG1 (12)
Clonality
monoclonal mc (17)
polyclonal pc (135)
Clone
7B11D6 (2)
8E9 (2)
8E9. (1)
ZC015 (1)
Format
AP Conjugated (9)
APC Conjugated (9)
Azide-free (3)
Biotin Conjugated (11)
FITC Conjugated (10)
HRP Conjugated (10)
PE Conjugated (9)
Unconjugated (94)
Epitope
pTyr245 (15)
aa231-260 (8)
aa613-641 (8)
aa851-881 (8)
pTyr134 (8)
pTyr185 (8)
pTyr204 (8)
pTyr412 (8)
pSer588 (7)
N-Terminus (3)
130-210 aa (2)
170-250 aa (2)
670-750 aa (2)
Ala198 (2)
C-Terminus (2)
Internal (2)
aa850-900 (2)
pThr735 (2)
830-910 aa, C-terminal (1)
Amino Acid: 577-650 (1)
Glu883 (1)
Leu406 (1)
SH2 Domain (1)
aa1020-1049 (1)
aa156-205 (1)
aa196-245 (1)
aa361-410 (1)
aa550-600 (1)
aa701-750 (1)
aa741-769 (1)
aa834-883 (1)
aa861-910 (1)
aa929-1020 (1)
pThr754/Thr735 (1)
pTyr393,pTyr412 (1)
pTyr393/412 (1)
pTyr89 (1)
Publications
No (152)
Showing 1-25 of 152 results

ABL1 / c-ABL Antibody (FITC) LS-C533725
Mouse Monoclonal (IgG1) to Human ABL1 / c-ABL
Mouse, Human
IF, IHC, IP, WB
FITC Conjugated
100µl  $890.00

IHC-plus™ ABL1 / c-ABL Antibody (clone 8E9., Azide-free) LS-B2776
Mouse Monoclonal [clone 8E9.] (IgG1) to Human ABL1 / c-ABL
Mouse, Human
IF, IHC, IHC-P, IP, WB
Unconjugated, Azide-free
50µg 1mg/ml  $485.00
Anti-ABL1 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. This image was taken for the unmodified form of this product. Other forms have not been tested.

ABL1 / c-ABL Antibody (AP) LS-C505755
Mouse Monoclonal (IgG1) to Human ABL1 / c-ABL
Mouse, Human
IF, IHC, IP, WB
AP Conjugated
100µl  $890.00

ABL1 / c-ABL Antibody (phospho-Tyr412) LS-C178071
Rabbit Polyclonal to Human ABL1 / c-ABL
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100µl  $345.00
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

ABL1 / c-ABL Antibody (aa850-900) LS-C288455
Rabbit Polyclonal (IgG) to Human ABL1 / c-ABL
Human
ICC, IF, IHC, IP
Unconjugated
100µl 1mg/ml  $395.00
Detection of Human cAbl by Immunohistochemistry and Immunocytochemistry. Sample: FFPE section of human ovarian carcinoma (left) and formaldehyde-fixed K562 cells (contains the chromosomal translocation, t(9:22) that creates the BCR/ABL fusion gene) (right). Antibody: Affinity purified rabbit anti-cAbl used at a dilution of 1:1000 (1 ug/ml). And Red-fluorescent goat anti-rabbit IgG cross-adsorbed Antibody used at a dilution of 1:100.

IHC-plus™ ABL1 / c-ABL Antibody (aa850-900) LS-B11050
Rabbit Polyclonal (IgG) to Human ABL1 / c-ABL
Human
ICC, IF, IHC, IHC-P
Unconjugated
50µl  $425.00
Anti-ABL1 / c-ABL antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Detection of Human cAbl by Immunocytochemistry. Sample: FFPE section of human K562 cells (contains the chromosomal translocation, t(9:22) that creates the BCR/ABL fusion gene). Antibody: Affinity purified rabbit anti-cAbl used at a dilution of 1:250.

ABL1 / c-ABL Antibody (830-910 aa, C-terminal) LS-C382408
Rabbit Polyclonal (IgG) to Human ABL1 / c-ABL
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of c-Abl antibody

IHC-plus™ ABL1 / c-ABL Antibody LS-B13844
Rabbit Polyclonal (IgG) to Human ABL1 / c-ABL
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50µl  $425.00
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Immunofluorescence analysis of A431 cells using ABL1 antibodyat dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

ABL1 / c-ABL Antibody (SH2 Domain, clone 8E9) LS-C88554
Mouse Monoclonal [clone 8E9] (IgG1) to Human ABL1 / c-ABL
Mouse, Human
IF, IHC, IHC-P, IP, WB
Unconjugated
0.1ml  $265.00; 0.5ml  $555.00; 1ml  $855.00
Formalin-fixed, paraffin-embedded human placenta stained with peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of trophoblasts.  This image was taken for the unmodified form of this product. Other forms have not been tested.

ABL1 / c-ABL Antibody (clone 8E9, Biotin) LS-C88555
Mouse Monoclonal [clone 8E9] (IgG1) to Human ABL1 / c-ABL
Mouse, Human
IF, IHC, IHC-P, IP, WB
Biotin Conjugated
0.1ml  $305.00; 0.5ml  $530.00; 1ml  $1,095.00
Formalin-fixed, paraffin-embedded human placenta stained with peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of trophoblasts.  This image was taken for the unmodified form of this product. Other forms have not been tested.

ABL1 / c-ABL Antibody (aa613-641, Azide-free, Biotin) LS-C250586
Rabbit Polyclonal (IgG) to Mouse ABL1 / c-ABL
Mouse
ELISA, IHC, WB
Biotin Conjugated, Azide-free
200µl  $740.00

ABL1 / c-ABL Antibody (phospho-Tyr204) LS-C127143
Rabbit Monoclonal (IgG) to Human ABL1 / c-ABL
Human
IP, WB
Unconjugated
100µl  $575.00

ABL1 / c-ABL Antibody (C-Terminus) LS-C353897
Rabbit Polyclonal to Human ABL1 / c-ABL
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $245.00
Immunohistochemical analysis of ABL1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of ABL1 staining in K562 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

ABL1 / c-ABL Antibody (phospho-Tyr412) LS-C800900
Rabbit Polyclonal (IgG) to Human ABL1 / c-ABL
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Immunofluorescence Image

ABL1 / c-ABL Antibody (phospho-Tyr393,pTyr412) LS-C800899
Rabbit Polyclonal (IgG) to Human ABL1 / c-ABL
Mouse, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Immunofluorescence Image

ABL1 / c-ABL Antibody LS-C801535
Rabbit Polyclonal (IgG) to Human ABL1 / c-ABL
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Immunofluorescence Image

ABL1 / c-ABL Antibody (phospho-Tyr412) LS-C127140
Rabbit Monoclonal (IgG) to Human ABL1 / c-ABL
Human
WB
Unconjugated
100µl  $575.00

ABL1 / c-ABL Antibody (phospho-Tyr89) LS-C127141
Rabbit Monoclonal (IgG) to Human ABL1 / c-ABL
Human
WB
Unconjugated
100µl  $575.00

ABL1 / c-ABL Antibody (phospho-Tyr245) LS-C127142
Rabbit Monoclonal (IgG) to Human ABL1 / c-ABL
Human
WB
Unconjugated
100µl  $575.00

ABL1 / c-ABL Antibody (aa550-600) LS-C288454
Rabbit Polyclonal (IgG) to Human ABL1 / c-ABL
Human
ICC, IF, IHC, IP, WB
Unconjugated
100µl 0.2mg/ml  $395.00
Detection of Human cAbl by Immunohistochemistry and Immunocytochemistry. Sample: FFPE section of human prostate carcinoma (left) and formaldehyde-fixed K562 cells (contains the chromosomal translocation, t(9:22) that creates the BCR/ABL fusion gene) (right). Antibody: Affinity purified rabbit anti-cAbl used at a dilution of 1:1000 (0.2 ug/ml) and 1:200 (1 ug/ml). And Red-fluorescent goat anti-rabbit IgG cross-adsorbed Antibody used at a dilution of 1:100.

ABL1 / c-ABL Antibody (phospho-Tyr393/412) LS-C416421
Rabbit Polyclonal to Human ABL1 / c-ABL
Mouse, Human
ICC, IF, IHC, WB
Unconjugated
100µg  $305.00
Western blot of Abl phosphorylation expression in RAW264.7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

ABL1 / c-ABL Antibody (aa741-769) LS-C99162
Rabbit Polyclonal to Human ABL1 / c-ABL
Human
IF, IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ABL1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Confocal immunofluorescence of ABL1 Antibody with MCF-7 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

ABL1 / c-ABL Antibody (N-Terminus) LS-C12193
Rabbit Polyclonal (IgG) to Human ABL1 / c-ABL
Mouse, Rat, Human
ELISA, Flo, ICC, WB
Unconjugated
100µl  $530.00

ABL1 / c-ABL Antibody (Glu883) LS-C177032
Rabbit Polyclonal to Human ABL1 / c-ABL
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100µl  $345.00
IHC of c-Abl (E883) pAb in paraffin-embedded human brain tissue.
Western blot of c-Abl (E883) pAb in extracts from 293 cells.

ABL1 / c-ABL Antibody (phospho-Tyr245) LS-C800901
Rabbit Polyclonal (IgG) to Human ABL1 / c-ABL
Mouse, Rat, Human, Monkey
ELISA, IF, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Immunofluorescence Image
Showing 1-25 of 152 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).