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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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ABL1 / c-ABL

c-abl oncogene 1, non-receptor tyrosine kinase

Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.

Gene Name: c-abl oncogene 1, non-receptor tyrosine kinase
Family/Subfamily: Protein Kinase , Abl
Synonyms: ABL1, Bcr/c-abl oncogene protein, Bcr-Abl, Bcr/abl, C-ABL, ABL, JTK7, p150, Tyrosine-protein kinase ABL1, Proto-oncogene c-Abl, V-abl
Target Sequences: NM_005157 NP_005148.2 P00519


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Mouse Monoclonal (IgG1) to Human ABL1 / c-ABL
Mouse, Human
IF, IHC, IP, WB
FITC Conjugated
100µl   $890.00
ABL1 / c-ABL Antibody - Anti-ABL1 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. This image was taken for the unmodified form of this product. Other forms have not been tested.
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Mouse Monoclonal [clone 8E9.] (IgG1) to Human ABL1 / c-ABL
Mouse, Human
IF, IHC, IHC-P, IP, WB
Unconjugated, Azide-free
50µg   1mg/ml   $485.00
ABL1 / c-ABL Antibody - Anti-ABL1 / c-ABL antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Rabbit Polyclonal (IgG) to Human ABL1 / c-ABL
Human
ICC, IF, IHC, IHC-P
Unconjugated
50µl   $425.00
ABL1 / c-ABL Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal (IgG) to Human ABL1 / c-ABL
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50µl   $425.00
ABL1 / c-ABL Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal to Human ABL1 / c-ABL
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100µl   $345.00
ABL1 / c-ABL Antibody - Detection of Human cAbl by Immunohistochemistry and Immunocytochemistry. Sample: FFPE section of human ovarian carcinoma (left) and formaldehyde-fixed K562 cells (contains the chromosomal translocation, t(9:22) that creates the BCR/ABL fusion gene) (right). Antibody: Affinity purified rabbit anti-cAbl used at a dilution of 1:1000 (1 ug/ml). And Red-fluorescent goat anti-rabbit IgG cross-adsorbed Antibody used at a dilution of 1:100.
Select
Rabbit Polyclonal (IgG) to Human ABL1 / c-ABL
Human
ICC, IF, IHC, IP
Unconjugated
100µl   1mg/ml   $405.00
ABL1 / c-ABL Antibody - Western blot of c-Abl antibody
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Rabbit Polyclonal (IgG) to Human ABL1 / c-ABL
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
ABL1 / c-ABL Antibody - Formalin-fixed, paraffin-embedded human placenta stained with peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of trophoblasts.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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Mouse Monoclonal [clone 8E9] (IgG1) to Human ABL1 / c-ABL
Mouse, Human
IF, IHC, IHC-P, IP, WB
Unconjugated
0.1ml   $265.00; 0.5ml   $555.00; 1ml   $855.00
ABL1 / c-ABL Antibody - Formalin-fixed, paraffin-embedded human placenta stained with peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of trophoblasts.  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone 8E9] (IgG1) to Human ABL1 / c-ABL
Mouse, Human
IF, IHC, IHC-P, IP, WB
Biotin Conjugated
0.1ml   $305.00; 0.5ml   $530.00; 1ml   $1,095.00
Select
Rabbit Polyclonal (IgG) to Mouse ABL1 / c-ABL
Mouse
ELISA, IHC, WB
Biotin Conjugated, Azide-free
200µl   $740.00
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Rabbit Monoclonal (IgG) to Human ABL1 / c-ABL
Human
IP, WB
Unconjugated
100µl   $575.00
ABL1 / c-ABL Antibody - Immunohistochemical analysis of ABL1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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Rabbit Polyclonal to Human ABL1 / c-ABL
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $245.00
ABL1 / c-ABL Antibody - 1:200 staining human colon carcinoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human ABL1 / c-ABL
Mouse, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
ABL1 / c-ABL Antibody - 1:200 staining human brain tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human ABL1 / c-ABL
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
ABL1 / c-ABL Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using Abl (Phospho-Tyr393/412) antibody.
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Rabbit Polyclonal (IgG) to Human ABL1 / c-ABL
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µg   $305.00
ABL1 / c-ABL Antibody - 1:100 staining human gastric tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human ABL1 / c-ABL
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Monoclonal (IgG) to Human ABL1 / c-ABL
Human
WB
Unconjugated
100µl   $575.00
Select
Rabbit Monoclonal (IgG) to Human ABL1 / c-ABL
Human
WB
Unconjugated
100µl   $575.00
Select
Rabbit Monoclonal (IgG) to Human ABL1 / c-ABL
Human
WB
Unconjugated
100µl   $575.00
ABL1 / c-ABL Antibody - Detection of Human cAbl by Immunohistochemistry and Immunocytochemistry. Sample: FFPE section of human prostate carcinoma (left) and formaldehyde-fixed K562 cells (contains the chromosomal translocation, t(9:22) that creates the BCR/ABL fusion gene) (right). Antibody: Affinity purified rabbit anti-cAbl used at a dilution of 1:1000 (0.2 ug/ml) and 1:200 (1 ug/ml). And Red-fluorescent goat anti-rabbit IgG cross-adsorbed Antibody used at a dilution of 1:100.
Select
Rabbit Polyclonal (IgG) to Human ABL1 / c-ABL
Human
ICC, IF, IHC, IP, WB
Unconjugated
100µl   0.2mg/ml   $405.00
ABL1 / c-ABL Antibody - Western blot of Abl phosphorylation expression in RAW264.7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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Rabbit Polyclonal to Human ABL1 / c-ABL
Mouse, Human
ICC, IF, IHC, WB
Unconjugated
50µg   50µl   1mg/ml   $255.00; 100µg   100µl   1mg/ml   $305.00
ABL1 / c-ABL Antibody - Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ABL1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Rabbit Polyclonal to Human ABL1 / c-ABL
Human
IF, IHC, IHC-P, WB
Unconjugated
400µl   $325.00
Select
Rabbit Polyclonal (IgG) to Human ABL1 / c-ABL
Mouse, Rat, Human
ELISA, Flo, ICC, WB
Unconjugated
100µl   $530.00
ABL1 / c-ABL Antibody - IHC of c-Abl (E883) pAb in paraffin-embedded human brain tissue.
Select
Rabbit Polyclonal to Human ABL1 / c-ABL
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   $345.00
ABL1 / c-ABL Antibody - 1:200 staining human brain tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22° C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human ABL1 / c-ABL
Mouse, Rat, Human, Monkey
ELISA, IF, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).