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ABI1 / SSH3BP1
abl-interactor 1
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
| Gene Name: | abl-interactor 1 |
| Synonyms: | ABI1, Abelson interactor 1, Abl-interactor protein 1 long, ABI-1, Abl-interactor 1, Abl interactor 1, Abl-binding protein 4, ABLBP4, NAP1BP, Nap1 binding protein, SSH3BP1, Nap1-binding protein, E3B1, Eps8-binding protein, Interactor protein AblBP4, SSH3BP |
| Target Sequences: | NM_005470 NP_005461.2 Q8IZP0 |
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