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ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
ABCE1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene.
| Gene Name: | ATP-binding cassette, sub-family E (OABP), member 1 |
| Family/Subfamily: | Transporter , ATP-binding cassette - ABCE/OABP |
| Synonyms: | ABCE1, ABC38, HuHP68, Ribonuclease 4 inhibitor, RLI, RNASELI, OABP, RNASEL1, RNase L inhibitor, RNS4I |
| Target Sequences: | NM_002940 NP_002931.2 P61221 |
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