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Unfortunately, the antibody LS-B8479 is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



ABCC6 / MRP6 Antibodies

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

Gene Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 6
Family/Subfamily: Transporter , ATP-binding cassette - ABCC/MRP
Synonyms: ABCC6 Antibody, ABC34 Antibody, EST349056 Antibody, MLP1 Antibody, MOAT-E Antibody, MRP6 Antibody, MOATE Antibody, URG7 Antibody, PXE1 Antibody, ARA Antibody, GACI2 Antibody, Pseudoxanthoma elasticum Antibody, PXE Antibody
Target Sequences: NM_001171 NP_001162.4 O95255
 ABCC6 / MRP6 Feature Table

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Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
ABCC6 / MRP6 Rat IgG1 Monoclonal M6II-21 Unconjugated Human IHC-P, IHC-Fr, ICC, WB, Flo No Primary
Anti-ABCC6 / MRP6 Antibody (clone M6II-21) LS-C202630
Rat Monoclonal [clone M6II-21] (IgG1) to Human ABCC6 / MRP6
Human
IHC - Paraffin, IHC - Frozen, ICC, Western blot, Flow Cytometry
Unconjugated
ABCC6 / MRP6 Rat IgG2a Monoclonal M6II-7 Unconjugated Human IHC-P, IHC-Fr, ICC, WB, Flo No Primary
Anti-ABCC6 / MRP6 Antibody (clone M6II-7) LS-C202629
Rat Monoclonal [clone M6II-7] (IgG2a) to Human ABCC6 / MRP6
Human
IHC - Paraffin, IHC - Frozen, ICC, Western blot, Flow Cytometry
Unconjugated
ABCC6 / MRP6 Rat IgG2a Monoclonal M6II-31 Unconjugated Human IHC-P, IHC-Fr, WB, Flo No Primary
Anti-ABCC6 / MRP6 Antibody (clone M6II-31) LS-C134868
Rat Monoclonal [clone M6II-31] (IgG2a) to Human ABCC6 / MRP6
Human
IHC - Paraffin, IHC - Frozen, Western blot, Flow Cytometry
Unconjugated
ABCC6 / MRP6 Rat IgG1 Monoclonal M6II-21 Unconjugated Human IHC-Fr, ICC, WB, Flo aa764-964 No Primary
Anti-ABCC6 / MRP6 Antibody (aa764-964, clone M6II-21) LS-C124155
Rat Monoclonal [clone M6II-21] (IgG1) to Human ABCC6 / MRP6
Human
IHC - Frozen, ICC, Western blot, Flow Cytometry
Unconjugated
ABCC6 / MRP6 Rat IgG1 Monoclonal M6II-7 Unconjugated Human IHC, ICC, WB aa764-964 No Primary
Anti-ABCC6 / MRP6 Antibody (aa764-964, clone M6II-7) LS-C124157
Rat Monoclonal [clone M6II-7] (IgG1) to Human ABCC6 / MRP6
Human
IHC, ICC, Western blot
Unconjugated
ABCC6 / MRP6 Mouse IgG2b,k Monoclonal 1E6 Unconjugated Human WB, ELISA No Primary
Anti-ABCC6 / MRP6 Antibody (clone 1E6) LS-C196680
ELISA Image
Mouse Monoclonal [clone 1E6] (IgG2b,k) to Human ABCC6 / MRP6
Human
Western blot, ELISA
Unconjugated
ABCC6 / MRP6 Rat IgG1 Monoclonal Unconjugated Human ICC, WB, ELISA aa764-964 No Primary
Anti-ABCC6 / MRP6 Antibody (aa764-964) LS-C25530
Rat Monoclonal (IgG1) to Human ABCC6 / MRP6
Human
ICC, Western blot, ELISA
Unconjugated
ABCC6 / MRP6 Mouse IgG Polyclonal Unconjugated Human WB No Primary
Anti-ABCC6 / MRP6 Antibody LS-C306024
Mouse Polyclonal (IgG) to Human ABCC6 / MRP6
Human
Western blot
Unconjugated
Type Target Reactivity Sample Type
Sandwich ABCC6 / MRP6 Mouse Tissue Homogenates
Mouse ABCC6 / MRP6 ELISA Kit - LS-F8525
Sandwich
Mouse
96-Well Strip Plate with Colorimetric - 450nm detection type
Tissue Homogenates
Sandwich ABCC6 / MRP6 Human Cell Lysates, Tissue Homogenates
Human ABCC6 / MRP6 ELISA Kit - LS-F9507
Sandwich
Human
96-Well Strip Plate with Colorimetric - 450nm detection type
Cell Lysates, Tissue Homogenates

ABCC6 / MRP6 Feature Table


Feature Type Location Details
Disease 1 - 1503 Defects in ABCC6 are the cause of pseudoxanthoma elasticum (PXE) [MIM:264800]. PXE is a disorder characterized by calcification of elastic fibers in skin, arteries and retina that results in dermal lesions with associated laxity and loss of elasticity, arterial insufficiency and retinal hemorrhages leading to macular degeneration. PXE is caused in the overwhelming majority of cases by homozygous or compound heterozygous mutations in the ABCC6 gene (autosomal recessive PXE). Individuals carrying heterozygous mutations express limited manifestations of the pseudoxanthoma elasticum phenotype (autosomal dominant PXE).
Function 1 - 1503 May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS).
sequence caution 1 - 1503 Sequence=AAC15785.1; Type=Erroneous gene model prediction;
Similarity 1 - 1503 Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Similarity 1 - 1503 Contains 2 ABC transmembrane type-1 domains.
Similarity 1 - 1503 Contains 2 ABC transporter domains.
Subcellular Location 1 - 1503 Membrane; Multi-pass membrane protein (By similarity). Note=Localized to the basolateral membrane.
Tissue Specificity 1 - 1503 Expressed in kidney and liver. Very low expression in other tissues.
web resource 1 - 1503 Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ABCC6";
web resource 1 - 1503 Name=Mutations of the ABCC6 gene; Note=Retina International's Scientific Newsletter; URL="http://www.retina-international.com/sci-news/abcc6mut.htm";
arrayexpress 1 - 1503 O95255
bgee 1 - 1503 O95255
cleanex 1 - 1503 HS_ABCC6
ctd 1 - 1503 368
doi 1 - 1503 10
embl 1 - 1503 AC136624
embl 1 - 1503 AF076622
embl 1 - 1503 AF168791
embl 1 - 1503 U91318
ensembl 1 - 1503 ENST00000205557
genecards 1 - 1503 GC16M016243
geneid 1 - 1503 368
genevestigator 1 - 1503 O95255
germonline 1 - 1503 ENSG00000091262
go 1 - 1503 GO:0005524
go 1 - 1503 GO:0007601
go 1 - 1503 GO:0016021
go 1 - 1503 GO:0042493
go 1 - 1503 GO:0042626
h-invdb 1 - 1503 HIX0026937
hgnc 1 - 1503 HGNC:57
hogenom 1 - 1503 HBG758042
hovergen 1 - 1503 HBG108314
inparanoid 1 - 1503 O95255
interpro 1 - 1503 IPR001140
interpro 1 - 1503 IPR003439
interpro 1 - 1503 IPR003593
interpro 1 - 1503 IPR005292
interpro 1 - 1503 IPR011527
interpro 1 - 1503 IPR017871
interpro 1 - 1503 IPR017940
ipi 1 - 1503 IPI00029455
medline 1 - 1503 20283940
medline 1 - 1503 20296630
medline 1 - 1503 20374463
medline 1 - 1503 20408303
medline 1 - 1503 20514578
medline 1 - 1503 21321623
medline 1 - 1503 21426347
medline 1 - 1503 21558431
medline 1 - 1503 21632106
medline 1 - 1503 21988190
medline 1 - 1503 99107222
medline 1 - 1503 99352020
medline 1 - 1503 99425270
mim 1 - 1503 177850
mim 1 - 1503 264800
mim 1 - 1503 603234
oma 1 - 1503 HQEEQMR
orphanet 1 - 1503 758
pfam 1 - 1503 PF00005
pfam 1 - 1503 PF00664
pharmgkb 1 - 1503 PA58
phylomedb 1 - 1503 O95255
prosite 1 - 1503 PS00211
prosite 1 - 1503 PS50893
prosite 1 - 1503 PS50929
proteinmodelportal 1 - 1503 O95255
pubmed 1 - 1503 10424734
pubmed 1 - 1503 10493829
pubmed 1 - 1503 10811882
pubmed 1 - 1503 10835642
pubmed 1 - 1503 10913334
pubmed 1 - 1503 10954200
pubmed 1 - 1503 11058917
pubmed 1 - 1503 11427982
pubmed 1 - 1503 11536079
pubmed 1 - 1503 11702217
pubmed 1 - 1503 11776382
pubmed 1 - 1503 11880368
pubmed 1 - 1503 12901863
pubmed 1 - 1503 15616553
pubmed 1 - 1503 17924679
pubmed 1 - 1503 18987736
pubmed 1 - 1503 19413330
pubmed 1 - 1503 9892204
refseq 1 - 1503 NP_001162.4
smart 1 - 1503 SM00382
smr 1 - 1503 O95255
string 1 - 1503 O95255
supfam 1 - 1503 SSF90123
tcdb 1 - 1503 3.A.1.208.10
tigrfams 1 - 1503 TIGR00957
unigene 1 - 1503 Hs.442182
alt_seq; genomic_dna 1 - 1503 AAC15785.1
not_annotated_cds; genomic_dna 1 - 1503 -
carbohyd 15 - 15 N-linked (GlcNAc...) (Probable)
chain 1 - 1503 Multidrug resistance-associated protein 6. /FTId=PRO_0000093366.
conflict 377 - 377 L -> P (in Ref. 4; AAD51293)
conflict 1274 - 1274 Y -> C (in Ref. 4; AAD51293)
conflict 1455 - 1455 L -> P (in Ref. 4; AAD51293)
domain 311 - 593 ABC transmembrane type-1 1
domain 629 - 853 ABC transporter 1
domain 947 - 1228 ABC transmembrane type-1 2
domain 1265 - 1499 ABC transporter 2
Modification 244 - 244 Phosphoserine (By similarity)
Modification 681 - 681 Phosphoserine
Modification 902 - 902 Phosphoserine
Modification 1310 - 1310 Phosphoserine
np_bind 663 - 670 ATP 1 (Potential)
np_bind 1299 - 1306 ATP 2 (Potential)
topo_dom 1 - 31 Extracellular (By similarity)
topo_dom 53 - 72 Cytoplasmic (By similarity)
topo_dom 94 - 98 Extracellular (By similarity)
topo_dom 120 - 131 Cytoplasmic (By similarity)
topo_dom 150 - 167 Extracellular (By similarity)
topo_dom 189 - 302 Cytoplasmic (By similarity)
topo_dom 324 - 349 Extracellular (By similarity)
topo_dom 371 - 426 Cytoplasmic (By similarity)
topo_dom 448 - 450 Extracellular (By similarity)
topo_dom 472 - 533 Cytoplasmic (By similarity)
topo_dom 555 - 575 Extracellular (By similarity)
topo_dom 597 - 939 Cytoplasmic (By similarity)
topo_dom 961 - 997 Extracellular (By similarity)
topo_dom 1019 - 1061 Cytoplasmic (By similarity)
topo_dom 1083 - 1083 Extracellular (By similarity)
topo_dom 1105 - 1175 Cytoplasmic (By similarity)
topo_dom 1197 - 1198 Extracellular (By similarity)
topo_dom 1220 - 1503 Cytoplasmic (By similarity)
transmem 32 - 52 Helical; Name=1; (By similarity)
transmem 73 - 93 Helical; Name=2; (By similarity)
transmem 99 - 119 Helical; Name=3; (By similarity)
transmem 132 - 149 Helical; Name=4; (By similarity)
transmem 168 - 188 Helical; Name=5; (By similarity)
transmem 303 - 323 Helical; Name=6; (By similarity)
transmem 350 - 370 Helical; Name=7; (By similarity)
transmem 427 - 447 Helical; Name=8; (By similarity)
transmem 451 - 471 Helical; Name=9; (By similarity)
transmem 534 - 554 Helical; Name=10; (By similarity)
transmem 576 - 596 Helical; Name=11; (By similarity)
transmem 940 - 960 Helical; Name=12; (By similarity)
transmem 998 - 1018 Helical; Name=13; (By similarity)
transmem 1062 - 1082 Helical; Name=14; (By similarity)
transmem 1084 - 1104 Helical; Name=15; (By similarity)
transmem 1176 - 1196 Helical; Name=16; (By similarity)
transmem 1199 - 1219 Helical; Name=17; (By similarity)
variant 60 - 62 Missing (in PXE; autosomal recessive) /FTId=VAR_013363.
variant 61 - 61 G -> D /FTId=VAR_013364.
variant 64 - 64 R -> W /FTId=VAR_013365.
variant 207 - 207 G -> R /FTId=VAR_013366.
variant 265 - 265 R -> G /FTId=VAR_013367.
variant 281 - 281 K -> E (in dbSNP:rs4780606) /FTId=VAR_013368.
variant 319 - 319 I -> V /FTId=VAR_013369.
variant 364 - 364 T -> R (in PXE; autosomal recessive) /FTId=VAR_013370.
variant 411 - 411 N -> K (in PXE; autosomal dominant) /FTId=VAR_013371.
variant 455 - 455 A -> P (in PXE; autosomal dominant) /FTId=VAR_013372.
variant 497 - 497 N -> K /FTId=VAR_013373.
variant 518 - 518 R -> Q (in PXE) /FTId=VAR_013374.
variant 568 - 568 F -> S (in PXE; autosomal dominant) /FTId=VAR_013375.
variant 614 - 614 V -> A (in dbSNP:rs12931472) /FTId=VAR_011490.
variant 632 - 632 H -> Q (in dbSNP:rs8058694) /FTId=VAR_013376.
variant 665 - 665 V -> A (in dbSNP:rs4341770) /FTId=VAR_055477.
variant 673 - 673 L -> P (in PXE; autosomal dominant) /FTId=VAR_013377.
variant 765 - 765 R -> Q (in PXE; autosomal dominant) /FTId=VAR_013378.
variant 848 - 848 M -> V (in dbSNP:rs6416668) /FTId=VAR_059108.
variant 953 - 953 L -> H /FTId=VAR_013379.
variant 1097 - 1097 L -> I (in dbSNP:rs60707953) /FTId=VAR_060988.
variant 1114 - 1114 R -> P (in PXE; autosomal recessive) /FTId=VAR_011491.
variant 1121 - 1121 S -> W (in PXE; autosomal dominant) /FTId=VAR_013380.
variant 1138 - 1138 R -> P (in PXE; autosomal dominant) /FTId=VAR_013381.
variant 1138 - 1138 R -> Q (in PXE; autosomal recessive; dbSNP:rs60791294). /FTId=VAR_011492.
variant 1138 - 1138 R -> W (in PXE; autosomal recessive; dbSNP:rs28939701). /FTId=VAR_011493.
variant 1203 - 1203 G -> D (in PXE; autosomal dominant) /FTId=VAR_013382.
variant 1241 - 1241 W -> C /FTId=VAR_013383.
variant 1268 - 1268 R -> Q (associated with lower plasma triglycerides and higher plasma HDL cholesterol; dbSNP:rs2238472). /FTId=VAR_011494.
variant 1298 - 1298 V -> F (in PXE; autosomal dominant; abolishes LTC4 and NEM-GS transport). /FTId=VAR_013384.
variant 1301 - 1301 T -> I (in PXE; autosomal dominant) /FTId=VAR_013385.
variant 1302 - 1302 G -> R (in PXE; autosomal dominant; abolishes LTC4 and NEM-GS transport). /FTId=VAR_013386.
variant 1303 - 1303 A -> P (in PXE; autosomal dominant) /FTId=VAR_013387.
variant 1314 - 1314 R -> Q (in PXE; autosomal dominant) /FTId=VAR_013388.
variant 1314 - 1314 R -> W (in PXE; autosomal recessive) /FTId=VAR_011495.
variant 1321 - 1321 G -> S (in PXE; autosomal dominant; abolishes LTC4 and NEM-GS transport). /FTId=VAR_013389.
variant 1339 - 1339 R -> C (in PXE; autosomal recessive; dbSNP:rs28939702). /FTId=VAR_013390.
variant 1347 - 1347 Q -> H (in PXE; autosomal dominant) /FTId=VAR_013391.
variant 1354 - 1354 G -> R (in PXE; autosomal recessive) /FTId=VAR_013392.
variant 1361 - 1361 D -> N (in PXE; autosomal dominant; dbSNP:rs58695352). /FTId=VAR_013393.
variant 1424 - 1424 I -> T (in PXE; autosomal dominant) /FTId=VAR_013394.
keyword 1 - 1503 ATP-binding
keyword 1 - 1503 Complete proteome
keyword 1 - 1503 Disease mutation
keyword 1 - 1503 Glycoprotein
keyword 1 - 1503 Membrane
keyword 1 - 1503 Nucleotide-binding
keyword 1 - 1503 Phosphoprotein
keyword 1 - 1503 Polymorphism
keyword 1 - 1503 Repeat
keyword 1 - 1503 Sensory transduction
keyword 1 - 1503 Transmembrane
keyword 1 - 1503 Transmembrane helix
keyword 1 - 1503 Transport
keyword 1 - 1503 Vision
Molecular Weight 1 - 1503 164906
2 hits 1 - 1503 PF00005
2 hits 1 - 1503 PF00664
2 hits 1 - 1503 PS00211
2 hits 1 - 1503 PS50893
2 hits 1 - 1503 PS50929

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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