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ABCC4 / MRP4

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

ABCC4 / MRP4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants.

Gene Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Family/Subfamily: Transporter , ATP-binding cassette - ABCC/MRP
Synonyms: ABCC4, EST170205, MOAT-B, Multidrug resistance protein 4, MOATB, MRP4
Target Sequences: NM_005845 NP_005836.2 O15439

Publications (4)

1
Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression. Xu S, Weerachayaphorn J, Cai SY, Soroka CJ, Boyer JL. American journal of physiology. Gastrointestinal and liver physiology. 2010 299:G126-35. [PubMed:20395535] [PMC:PMC2904108] Related Antibodies: LS-B4.
2
Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine. Weerachayaphorn J, Mennone A, Soroka CJ, Harry K, Hagey LR, Kensler TW, Boyer JL. American journal of physiology. Gastrointestinal and liver physiology. 2012 302:G925-36. (WB; Mouse) [PubMed:22345550] [PMC:PMC3362073] Related Antibodies: LS-B4.
3
Transporter function and cyclic AMP turnover in normal colonic mucosa from patients with and without colorectal neoplasia. Kleberg K, Jensen GM, Christensen DP, Lundh M, Grunnet LG, Knuhtsen S, Poulsen SS, Hansen MB, Bindslev N. BMC gastroenterology. 2012 12:78. (IHC; Human) [Full Text Article] [PubMed:22734885] [PMC:PMC3457850] Related Antibodies: LS-B4.
4
Expression and activity of multidrug resistance proteins in mature endothelial cells and their precursors: A challenging correlation. Krawczenko A, Bielawska-Pohl A, Wojtowicz K, Jura R, Paprocka M, Wojdat E, Kozlowska U, Klimczak A, Grillon C, Kieda C, DuÅ› D. PloS one. 2017 12:e0172371. (ICC; Human) [Full Text Article] [PubMed:28212450] [PMC:PMC5315393] Related Antibodies: LS-C146610.
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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
ABCC4 / MRP4 (5)
No (5)
GST, N-terminus (1)
His (2)
Myc-DDK (Flag) (2)
Human (4)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Low endotoxin level (1)
ABCC4 / MRP4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
96.7 kDa
20 µg/$215
ABCC4 / MRP4 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ABCC4 / MRP4 Protein - Recombinant ATP Binding Cassette Transporter C4 By SDS-PAGE
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E. coli
His
30.2 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
ABCC4 / MRP4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
96.7 kDa
100 µg/$710
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E. coli
91 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
10.12 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).