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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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ABCC2 / MRP2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
| Gene Name: | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
| Family/Subfamily: | Transporter , ATP-binding cassette - ABCC/MRP |
| Synonyms: | ABCC2, ABC30, CMOAT1, CMOAT, DJS, Multidrug resistance protein 2, MRP2, CMRP |
| Target Sequences: | NM_000392 NP_000383.1 Q92887 |
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