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ABCB8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants.
| Gene Name: | ATP-binding cassette, sub-family B (MDR/TAP), member 8 |
| Family/Subfamily: | Transporter , ATP-binding cassette - ABCB/MDR |
| Synonyms: | ABCB8, MABC1, M-ABC1, Mitochondrial ABC protein, EST328128 |
| Target Sequences: | NM_007188 NP_009119.2 Q9NUT2 |
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