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ABCB5

ATP-binding cassette, sub-family B (MDR/TAP), member 5

Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.

Gene Name: ATP-binding cassette, sub-family B (MDR/TAP), member 5
Family/Subfamily: Transporter , ATP-binding cassette - ABCB/MDR
Synonyms: ABCB5, ABCB5alpha, ABCB5 P-gp, ABCB5beta, ATP-binding cassette protein, EST422562, P-glycoprotein ABCB5
Target Sequences: NM_178559 NP_848654.3 Q2M3G0

Publications (2)

1
Evaluation of a multi-marker immunomagnetic enrichment assay for the quantification of circulating melanoma cells. Freeman JB, Gray ES, Millward M, Pearce R, Ziman M. Journal of translational medicine. 2012 10:192. [PubMed:22978632] [PMC:PMC3480925] Related Antibodies: LS-B3454.
2
Targeting melanoma stem cells with the Vitamin E derivative d-tocotrienol. Marzagalli M, Moretti RM, Messi E, Marelli MM, Fontana F, Anastasia A, Bani MR, Beretta G, Limonta P. Scientific reports. 2018 8:587. (ICC; Human) [Full Text Article] [PubMed:29330434]

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Proteins (3)
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ABCB5 (3)
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TRX, N-terminus (2)
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E. coli
TRX, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
29.4kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
ABCB5 Protein - Recombinant  ATP Binding Cassette Transporter B5 By SDS-PAGE
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E. coli
His-S
30.1 kDa
10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136
Select
E. coli
TRX, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
29.4 kDa
10 µg/$317; 50 µg/$524
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).